JOURNAL OF PUBLIC HEALTH AND DISEASES
Integrity Research Journals

ISSN: 2705-2214
Model: Open Access/Peer Reviewed
DOI: 10.31248/JPHD
Start Year: 2018
Email: jphd@integrityresjournals.org


Impact of HIV/AIDS on mother-to-child transmission and health outcomes in children under five years in Nsukka Local Government Area of Enugu State

https://doi.org/10.31248/JPHD2025.175   |   Article Number: A23C175E5   |   Vol.8 (1) - April 2026

Received Date: 27 October 2025   |   Accepted Date: 23 December 2025  |   Published Date: 30 April 2026

Authors:  E. D. Ubanwa* , L. O. Nsude and G. Y. Benjamin

Keywords: prevalence, HIV, Conception, paediatric, questionnaire.

The impact of HIV on the health transmission of Paediatric is largely unknown in many countries in sub-Saharan Africa (SSA). This work aimed to determine the prevalence and the impact of HIV infection among children under 5 years old in Nsukka Local Government Area. Methods: A facility-based study among mothers/guardians with their under-5 years children exposed to HIV infection. Information on HIV status, socio-demographic and other family characteristics was collected using a structured questionnaire. Data analysis was performed using STATA version 13.0. Results showed that 876 children under five years old who were HIV-exposed were recruited, along with their mothers or guardians. The HIV prevalence among under-5-year-old children was 9.70% (95% CI: 7.1-12.1%). The burden of HIV infection was observed to be higher among females 10.3% than male 8.72%, within older children aged 24 to 36 months (AOR = 7.0, 95% CI 2.4 - 25.1) than in the younger children. There was a four-fold (AOR=3.9, 95% CI 1.7-9.1) risk of HIV infection among children born to mothers of unknown HIV status at conception than among children born to mothers with known HIV status. The odds of HIV infection were higher among children who were delivered from home (AOR = 2.6, 95% CI 1.0-6.5), received mixed feeding (AOR = 2.4, 95% CI 1.2-4.9), and those living far from a health facility (AOR = 3.0, 95% CI 1.4-6.5). In conclusion, the prevalence of HIV among children under 5 years old in Nsukka LGA is higher among older children. The high prevalence is associated with being born to mothers with unknown HIV status at conception, receiving mixed feeding, home delivery, and living far from the health facility. Campaigns that provide health educational messages addressing risk factors of HIV need to be emphasised to promote the control and prevention of HIV among children.

Adejuyigbe, E. A., Oyelami, O., Onayemi, O., & Durosinmi, M. A. (2003). Paediatric HIV/AIDS in Ile-Ife, Nigeria. The Central African Journal of Medicine, 49(7-8), 74-78.
 
Akpede, G. O., Lawal, R. S., & Momoh, S. O. (2002). Perception of voluntary screening for paediatric HIV and response to post-test counselling by Nigerian parents. AIDS Care, 14(5), 683-697.
https://doi.org/10.1080/0954012021000005515
 
Angyo, I. A., Okpeh, E. S., & Onah, J. (1998). Paediatric AIDS in Jos, Nigeria. West African Journal of Medicine, 17(4), 268-272.
 
Bakaki, P., Kayita, J., Machado, J. E. M., Coulter, B. J., Tindyebwa, D., Ndugwa, C. M., & Hart, A. C. (2001). Epidemiologic and clinical features of HIV-infected and HIV-uninfected Ugandan children younger than 18 months. JAIDS Journal of Acquired Immune Deficiency Syndromes, 28(1), 35-42.
https://doi.org/10.1097/00042560-200109010-00006
 
Bwana, V. M., Frimpong, C., Simulundu, E., Mfinanga, S. G., Mboera, L. E., & Michelo, C. (2016). Accessibility of services for early infant diagnosis of Human Immunodeficiency Virus in sub-Saharan Africa: a systematic review. Tanzania journal of health research, 18(3), 1-18.
https://doi.org/10.4314/thrb.v18i3.9
 
Coutsoudis, A., Pillay, K., Kuhn, L., Spooner, E., Tsai, W. Y., Coovadia, H. M., & South African Vitamin A Study Group. (2001). Method of feeding and transmission of HIV-1 from mothers to children by 15 months of age: prospective cohort study from Durban, South Africa. Aids, 15(3), 379-387.
https://doi.org/10.1097/00002030-200102160-00011
 
Emodi, I. J., & Okafor, G. O. (1998). Clinical manifestations of HIV infection in children at Enugu, Nigeria. Journal of tropical pediatrics, 44(2), 73-76.
https://doi.org/10.1093/tropej/44.2.73
 
Fawzi, W., Msamanga, G., Spiegelman, D., Renjifo, B., Bang, H., Kapiga, S., ... & Hunter, D. (2002). Transmission of HIV-1 through breastfeeding among women in Dar es Salaam, Tanzania. JAIDS Journal of Acquired Immune Deficiency Syndromes, 31(3), 331-338.
https://doi.org/10.1097/00126334-200211010-00010
 
Hill, A., Clayden, P., Thorne, C., Christie, R., & Zash, R. (2018). Safety and pharmacokinetics of dolutegravir in HIV-positive pregnant women: a systematic review. Journal of virus eradication, 4(2), 66-71.
https://doi.org/10.1016/S2055-6640(20)30247-8
 
Jones, D. S., Byers, R. H., Bush, T. J., Oxtoby, M. J., & Rogers, M. F. (1992). Epidemiology of transfusion-associated acquired immunodeficiency syndrome in children in the United States, 1981 through 1989. Pediatrics, 89(1), 123-127.
https://doi.org/10.1542/peds.89.1.123
 
Karande, S., Bhalke, S., Kelkar, A., Ahuja, S., Kulkarni, M., & Mathur, M. (2002). Utility of Clinically‐directed Selective Screening to Diagnose HIV Infection in Hospitalized Children in Bombay, India. Journal of Tropical Pediatrics, 48(3), 149-155.
https://doi.org/10.1093/tropej/48.3.149
 
Kilewo, C., Karlsson, K., Ngarina, M., Massawe, A., Lyamuya, E., Swai, A., Lipyoga, R., Mhalu, F., Biberfeld, G., & Mitra Plus Study Team. (2009). Prevention of mother-to-child transmission of HIV-1 through breastfeeding by treating mothers with triple antiretroviral therapy in Dar es Salaam, Tanzania: the Mitra Plus study. JAIDS Journal of Acquired Immune Deficiency Syndromes, 52(3), 406-416.
https://doi.org/10.1097/QAI.0b013e3181b323ff
 
Lucas, S. B., Peacock, C. S., Hounnou, A., Brattegaard, K., Koffi, K., Honde, M., Andoh, J., Bell, J., & De Cock, K. M. (1996). Disease in children infected with HIV in Abidjan, Cote d'Ivoire. Bmj, 312(7027), 335-338.
https://doi.org/10.1136/bmj.312.7027.335
 
Oniyangi, O., Awani, B., & Iregbu, K. C. (2006). The pattern of paediatric HIV/AIDS as seen at the National Hospital Abuja Nigeria. Nigerian Journal of Clinical Practice, 9(2), 153-158.
 
Spira, R., Lepage, P., Msellati, P., Van de Perre, P., Leroy, V., Simonon, A., ... & Mother-to-Child HIV-1 Transmission Study Group. (1999). Natural history of human immunodeficiency virus type 1 infection in children: a five-year prospective study in Rwanda. Pediatrics, 104(5), e56-e56.
https://doi.org/10.1542/peds.104.5.e56
 
Taha, T. E., & Gray, R. H. (2000). Genital tract infections and perinatal transmission of HIV. Annals of the New York Academy of Sciences, 918(1), 84-98.
https://doi.org/10.1111/j.1749-6632.2000.tb05477.x
 
Taha, T. E., Nour, S., Kumwenda, N. I., Broadhead, R. L., Fiscus, S. A., Kafulafula, G., Nkhoma, C., Chen, S., & Hoover, D. R. (2005). Gender differences in perinatal HIV acquisition among African infants. Pediatrics, 115(2), e167-e172.
https://doi.org/10.1542/peds.2004-1590
 
Ugochukwu, E. F. (2006). Clinical spectrum of paediatric HIV in Nnewi, Nigeria. West African Journal of Medicine, 25(1), 10-16.
https://doi.org/10.4314/wajm.v25i1.28238
 
UNAIDS/WHO (2007). Guidance on provider-initiated HIV testing and counselling in health facilities. Geneva: Joint United Nations Programme on HIV/AIDS (UNAIDS) and World Health Organisation (WHO), pp. 1-60.
 
UNICEF (2015). State of the World's Children. NEWYORK CITY 2007
https://doi.org/10.1017/CBO9780511511271
 
Wagner, A., Slyker, J., Langat, A., Inwani, I., Adhiambo, J., Benki-Nugent, S., Tapia, K., Njuguna, I., Wamalwa, D., & John-Stewart, G. (2015). High mortality in HIV-infected children diagnosed in hospital underscores need for faster diagnostic turnaround time in prevention of mother-to-child transmission of HIV (PMTCT) programs. BMC Pediatrics, 15(1), 10.
https://doi.org/10.1186/s12887-015-0325-8
 
World Health Organisation (WHO) (2006). Antiretroviral therapy of HIV infection in infants and children in resource-limited settings, towards universal access: Recommendations for a public health approach (2006 revision). Geneva: World Health Organisation.
 
World Health Organisation (WHO) (2020). Antiretroviral drugs for treating pregnant women and preventing HIV infection in infants: Recommendations for a Public Health Approach. Geneva, Switzerland, World Health Organisation.
 
World Health Organisation (WHO) (2022). Mother-to-child transmission of HIV - Global HIV Programme. Retrieved from https://www.who.int/teams/global-hiv-hepatitis-and-stis-programmes/hiv/prevention/mother-to-child-transmission-of-hiv.