JOURNAL OF PUBLIC HEALTH AND DISEASES
Integrity Research Journals

ISSN: 2705-2214
Model: Open Access/Peer Reviewed
DOI: 10.31248/JPHD
Start Year: 2018
Email: jphd@integrityresjournals.org


Prevalence of allergens of atopic asthma at Square Hospitals Limited, Dhaka, Bangladesh

https://doi.org/10.31248/JPHD2020.098   |   Article Number: 21DEB6392   |   Vol.3 (6) - December 2020

Received Date: 20 November 2020   |   Accepted Date: 08 December 2020  |   Published Date: 30 December 2020

Authors:  Fairoze Masuda Akther and Hamida Khanum*

Keywords: Allergens, atopic asthma, allergy, family history, skin prick test, serum immunoglobulin E level, risk factors.

Asthma is one of the major substantial public health problems, caused by both the genetic and the environmental factors (allergens and air pollution). Here, the prevalence of allergens of atopic asthma was investigated and carried out at Square Hospitals Limited., Dhaka from November 2019 to July 2020. The study group consisted of 168 asthmatic subjects who suffered from asthma. Skin prick test of 56 listed allergens, serum immunoglobulin E level, and clinical history were assessed to investigate the prevalence. The survey depicted an 80% positive reaction to Dermatophagoides farinae and a 71% to Dermatophagoides pteronyssinus. For these allergens, a high prevalence was recorded in males (50% and 47.02%) who belonged to the age group of 26 to 45 years (28.57% and 24.40% respectively). Furthermore, the significance of family history of allergy (51.79% and 48.81%) and medication history (41.07% and 39.29%) was found to be substantial for these allergens. Additionally, 57% of respondents were tested positive for dog epithelia and cockroach allergens, 56% for grain (wheat) dust, 44% to mosquito allergen, 42% for house dust and Aspergillus fumigatus, 36% to chicken feather, 35% for pigeon feather, and 6% to latex. Moreover, 80.36% of respondents had elevated serum immunoglobulin E level concerning their ages and 11.90% did not have serum reports. Interestingly, the respondents who had no family history of allergy were found to be more allergic to fungi allergens. Lastly, 39.1% of respondents were allergic to different kinds of foods like aquatic or seafood, animal products, dairy products, fruits, and vegetables. Among the respondents, 64.9% reported to have a positive family history. Association and correlation of allergens with different risk factors were analyzed and it was concluded that people predominantly suffered from mite allergens followed by animal dander, insect, dust, fungi and pollen, and a minute amount of latex allergens.

Alderson, M. (1987). Trends in morbidity and mortality from asthma. Population Treads, 49, 18-23.
 
Anandan, C., Nurmatov, U., van Schayck, O. C. P., Sheikh, A. (2010). Is the prevalence of asthma Declining? Systematic review of epidemiological studies. European Journal of Allergy and Clinical immunology, 65(2), 152-167.
Crossref
 
Anuradha, A., Lakshimi Kalpana, V., &Narasingaro, S. (2011). Epidemiology study on bronchial asthma. Indian Journal Allergy Asthma Immunol, 3(12), 434-436.
 
Asher, I., & Pearce, N. (2014). Global burden of asthma among children. The International Journal of Tuberculosis and Lung Disease, 18(11), 1269-1278.
Crossref
 
Bantz, S. K., Zhu, Z., & Zheng, T. (2014). The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma. Journal of Clinical and Cellular Immunology, 5(2), 202.
 
Barbee, R. A., Lebowitz, M. D., Thompson, H. C., & Burrows, B. (1976). Immediate skin-test reactivity in a general population sample. Annals of Internal Medicine, 84(2), 129-133.
Crossref
 
Barua, U. K., Saha, S. K., Ghosh, D. K., & Ruble, M. M. K. (2013). Epidemiological study on bronchial asthma at Shaheed Suhrawardy Medical College Hospital, Dhaka. Journal of Shaheed Suhrawardy Medical College, 5(2), 77-80.
Crossref
 
Baxi, S. N., & Phipatanakul, W. (2010). The role of allergen exposure and avoidance in asthma. Adolescent Medicine: State of the Art Reviews, 21(1), 57-71
 
Blanco, C., Carrillo, T., Ortega, N., Alvarez, M., Dominguez, C., & Castillo, R. (1998). Comparison of skin-prick test and specific serum IgE determination for the diagnosis of latex allergy. Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology, 28(8), 971-976.
Crossref
 
Burbank, A. J., Sood, A. K., Kesic, M. J., Peden, D. B., & Hernandez, M. L. (2017). Environmental determinants of allergy and asthma in early life. Journal of Allergy and Clinical Immunology, 140(1), 1-12.
Crossref
 
Campo, P., Eguiluz‐Gracia, I., Plaza‐Serón, M. C., Salas, M., José Rodríguez, M., Pérez‐Sánchez, N., González, M., Molina, A., Mayorga, C., Torres, M. J., & Rondón, C. (2019). Bronchial asthma triggered by house dust mites in patients with local allergic rhinitis. Allergy: European Journal of Allergy and Clinical Immunology, 74(8), 1502-1510.
Crossref
 
Olbrich, C. L., Bivas-Benita, M., Xenakis, J. J., Maldonado, S., Cornwell, E., Fink, J., Yuan, Q., Gill, N., Mansfield, R., Dockstader, K., & Spencer, L. A. (2020). Remote allergen exposure elicits eosinophil infiltration into allergen nonexposed mucosal organs and primes for allergic inflammation. Mucosal Immunology, 13, 777-78.
Crossref
 
Del Giacco, S. R., Bakirtas, A., Bel, E., Custovic, A., Diamant, Z., Hamelmann, E., Heffler, E., Kalayci, Ö., Saglani, S., Sergejeva, S., & Seys, S. (2017). Allergy in severe asthma. Allergy: European Journal of Allergy and Clinical Immunology, 72(2), 207-220.
Crossref
 
Denning, D. W., Pashley, C., Hartl, D., Wardlaw, A., Godet, C., Del Giacco, S., Delhaes, L., & Sergejeva, S. (2014). Fungal allergy in asthma-state of the art and research needs. Clinical and Translational Allergy, 4, Article number 14.
Crossref
 
Dierick, B. J., van der Molen, T., Flokstra-de Blok, B. M., Muraro, A., Postma, M. J., Kocks, J. W., & van Boven, J. F. (2020). Burden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy. Expert Review of Pharmacoeco-nomics and Outcomes Research, 20(5), 437-453.
Crossref
 
Frith, J., Fleming, L., Bossley, C., Ullmann, N., & Bush, A. (2011). The complexities of defining atopy in severe childhood asthma. Clinical and Experimental Allergy, 41(7), 948-953.
Crossref
 
Hendrick, D. J., Davies, R. J., D'souza, M. F., & Pepys, J. (1975). An analysis of skin prick test reactions in656 asthmatic patients. Department of Clinical Immunology, Cardiothoracic Institute, Brompton Hospital, London. Thorax, 30, 2.
Crossref
 
Just, J., Gouvis - Echraghi, R., Rouve, S., Wanin, S., Moreau, D., & Annesi-Maesano, I. (2012). Two novel, severe asthma phenotypes identified during childhood using a clustering approach. European Respiratory Journal, 40(1), 55-60.
Crossref
 
Kader, R., Kennedy, K., & Portnoy, J. M. (2018). Indoor environmental interventions and their effect on asthma outcomes. Current Allergy and Asthma Reports, 18, Article Number17.
Crossref
 
Kanchongkittiphon, W., Mendell, M. J., Gaffin, J. M., Wang, G., Phipatanakul, W. (2015). Indoor environmental exposures and exacerbation of asthma: an update to the 2000 review by the Institute of Medicine. Environmental Health Perspectives, 123(1), 6-20.
Crossref
 
Krogulska, A., Dynowski, J., Funkowicz, M., Małachowska, B., & Wąsowska-Królikowska, K. (2015). Prevalence and clinical impact of IgE-mediated food allergy in school children with asthma: a double-blind placebo-controlled food challenge study. Allergy, Asthma and Immunology Research, 7(6), 547-556.
Crossref
 
Krogulska, A., Dynowski, J., Jędrzejczyk, M., Sardecka, I., Małachowska, B., & Wąsowska‐Królikowska, K. (2016). The impact of food allergens on airway responsiveness in schoolchildren with asthma: A DBPCFC study. Pediatric Pulmonology, 51(8), 787-795.
Crossref
 
Murray, C. S. P. G., Ahlstedt, S., Soderstrom, L., Johnston, S. L., & Custovic, A. (2007). Probability of hospital admission with acute asthma exacerbation increases with increasing specific IgE antibody levels. Allergy and Clinical Immunology International, 2, 270-273.
 
Murrison, L. B., Brandt, E. B., Myers, J. B., & Hershey, G. K. K. (2019). Environmental exposures and mechanisms in allergy and asthma development. The Journal of Clinical Investigation, 129(4), 1504-1515.
Crossref
 
Pearce, N., Pekkanen, J., & Beasley, R. (1999). How much asthma is really attributable to atopy? Thorax, 54(3), 268-272.
Crossref
 
Pepys, J., & Hutchcroft, B. J. (1975). Bronchial provocation tests in etiologic diagnosis and analysis of asthma. American Review of Respiratory Disease, 112(6), 829-859.
 
Rai, S. P., Patil, A. P., Vardhan, V., Marwah, V., Pethe, M., & Pandey, I. M. (2007). Best treatment guidelines for bronchial asthma. Medical Journal Armed Forces India, 63(3), 264-268.
Crossref
 
Schoos, A. M. M., Chawes, B. L., Rasmussen, M. A., Bloch, J., Bønnelykke, K., & Bisgaard, H. (2016). Atopic endotype in childhood. Journal of Allergy and Clinical Immunology, 137(3), 844-851.
Crossref
 
Schwartz, H. J., Citron, K. M., Chester, E. H., Kaimal, J., Barlow, P. B., Baum, G. L., & Schuyler, M. R. (1978). A comparison of the prevalence of sensitization to Aspergillus antigens among asthmatics in Cleveland and London. Journal of Allergy and Clinical Immunology, 62(1), 9-14.
Crossref
 
Sears, M. R., Holdaway, M. D., Flannery, E. M., Herbison, G. P., & Silva, P. A. (1996). Parental and neonatal risk factors for atopy, airway hyper-responsiveness, and asthma. Archives of Disease in Childhood, 75(5), 392-398.
Crossref
 
Spergel, J. M. (2005). Atopic march: link to upper airways. Current opinion in allergy and clinical immunology, 5(1), 17-21.
Crossref
 
Spergel, J. M. (2010). Epidemiology of atopic dermatitis and atopic march in children. Immunology and Allergy Clinics, 30(3), 269-280.
Crossref
 
Thaminy, A., Lamblin, C., Perez, T., Bergoin, C., Tonnel, A. B., & Wallaert, B. (2000). Increased frequency of asymptomatic bronchial hyperresponsiveness in nonasthmatic patients with food allergy. European Respiratory Journal, 16(6), 1091-1094.
Crossref
 
Ubags, N. D. (2020). Remote tissue immune priming in allergic disease. Mucosal Immunology, 13(5), 719-720.
Crossref
 
van der Hulst, A. E., Klip, H., & Brand, P. L. (2007). Risk of developing asthma in young children with atopic eczema: a systematic review. Journal of Allergy and Clinical Immunology, 120(3), 565-569.
Crossref
 
Vandenplas, O., Froidure, A., Meurer, U., Rihs, H. P., Rifflart, C., Soetaert, S., Jamart, J., Pilette, C., & Raulf, M. (2016). The role of allergen components for the diagnosis of latex‐induced occupational asthma. Allergy: European Journal of Allergy and Clinical Immunology, 71(6), 840-849.
Crossref
 
Vohlonen, I., Terho, E. O., Koivikko, A., Vanto, T., Holmen, A., & Heinonen, O. P. (1989). Reproducibility of the skin prick test. Allergy: European Journal of Allergy and Clinical Immunology, 44(8), 525-531.
Crossref
 
Wang, J., & Liu, A. H. (2011). Food allergies and asthma. Current Opinion in Allergy and Clinical Immunology, 11(3), 249-254.
Crossref
 
Weiland, S. K., Hüsing, A., Strachan, D. P., Rzehak, P., Pearce, N., & the ISAAC phase one study group (2004). Climate and the prevalence of symptoms of asthma, allergic rhinitis, and atopic eczema in children. Occupational and Environmental Medicine, 61(7), 609-615.
Crossref