Journal of Public Health and Diseases

JOURNAL OF PUBLIC HEALTH AND DISEASES
Integrity Research Journals

ISSN: 2705-2214
Model: Open Access/Peer Reviewed
DOI: 10.31248/JPHD
Start Year: 2018
Email: jphd@integrityresjournals.org

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Dose dependent effect of Gacinia kola ethanolic extract on sperm profile in fasting induced male Wistar rats

https://doi.org/10.31248/JPHD2025.174   |   Article Number: 0F097D3F3   |   Vol.7 (5) - October 2025

Received Date: 23 September 2025   |   Accepted Date: 29 October 2025  |   Published Date: 30 October 2025

Authors:  Kianen Sekiita , Charles Ngaikedi N. , Emily Kiridi G.E. and Solomon M. Uvoh*

Keywords: rats, Hormones, Extract, G. kola, sperm.

ABSTRACT

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This research determines the effects of starvation-induced stress and G. kola ethanolic extracts on sperm indices using male rats. Thirty (30) male rats that weigh 110-130g were purchased from the faculty of BMS and acclimatised for 2 weeks. They were separated into GP1 (control), GP2 15 hours normal diet and water with 9 hours fasting, GP3 6 hours normal diet and water with 18 hours fasting and GP4, 5 and 6 were treated at 25, 50 and 100 mg/kg G. kola ethanolic extract daily for 4 weeks. Sperm count was calculated using the hemocytometer method. The findings from this study show a significant decrease in sperm count among the group treated with G. kola ethanolic extract at different doses compared with the control. There was an increase in progressive sperm motility at 50 and 100 mg doses compared with the control. Moreover, a significant increase in non-progressive sperm motility was observed among treated groups with G. kola ethanolic extract compared with the control. However, there was a non-significant change in immotile sperm count at different concentrations with G. kola extract. Regarding fasting hours on sperm count, there were no significant changes compared with the control group. In conclusion, the study reveals that ethanolic extracts of G. kola possibly contain certain phytochemical constituents that induced deleterious effects in male sperm profile on prolonged consumption.

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