JOURNAL OF PUBLIC HEALTH AND DISEASES
Integrity Research Journals
ISSN: 2705-2214
Model: Open Access/Peer Reviewed
DOI: 10.31248/JPHD
Start Year: 2018
Email: jphd@integrityresjournals.org
Prevalence and characterization of Salmonella typhi isolated from internally displaced persons in Jos, Plateau State, Nigeria
https://doi.org/10.31248/JPHD2022.122 | Article Number: 0727C28A1 | Vol.5 (5) - December 2022
Received Date: 19 October 2022 | Accepted Date: 12 December 2022 | Published Date: 30 December 2022
Authors: Olufunke Olufunmilola Olorundare* , Grace Mebi Ayanbimpe , Noel Denaan Dawang and Nnaemeka Emmanuel Nnadi
Keywords: prevalence, Disease, Plateau State, isolates, Jos, Salmonella typhi.
Salmonella typhi, is estimated to cause 21.6 million illnesses and 216,000 deaths. The plight of displaced persons has in recent times become a formidable problem of global significance and implication. This work was aimed at isolating and characterizing S. typhi from two internally displaced camps in Jos, Plateau State, Nigeria. A total of 183 stool samples were collected randomly and cultured. Isolates were serotyped and identified by PCR targeting the invasive gene. An antimicrobial susceptibility test was carried out on isolates using the disc diffusion method. The study showed a prevalence of 1.1% for S. typhi and 1.6% for non-typhoid Salmonella. All the isolates were sensitive to ciprofloxacin, ofloxacin ceftriaxone, chloramphenicol and gentamicin except for nalidixic acid and cefuroxime. The Salmonella typhi isolates were sequenced using Fastp for quality control and the genotype was determined. Comparative genomics on the two S. typhi assembled showed S. typhi 1(SO1) contains 38 contigs and S. typhi 2 (SO2) had 35 contigs. The result shows that the genome is similar to the reference strain CT18. More care and adequate health facilities should be provided in other to further reduce the rate of infection in the IDP camps.
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