JOURNAL OF BIOSCIENCE AND BIOTECHNOLOGY DISCOVERY
Integrity Research Journals
ISSN: 2536-7064
Model: Open Access/Peer Reviewed
DOI: 10.31248/JBBD
Start Year: 2016
Email: jbbd@integrityresjournals.org
Role of vitamin D receptor (VDR) genetic polymorphism in onset of type 2 diabetes mellitus: A Review
https://doi.org/10.31248/JBBD2018.077 | Article Number: CC553B791 | Vol.4 (1) - February 2019
Received Date: 02 August 2018 | Accepted Date: 11 September 2018 | Published Date: 28 February 2019
Authors: Naila Abdul Sattar* , Fatma Hussain , Kathleen Gillespie , Siraj Udin Sajid , Sumera Shaheen , Nusrat Shafiq , Sobia Aleem and Sadia Aslam
Keywords: Pathogenesis, T2DM, VDR polmorphism.
Numerous studies disclosed the independent role of VDR genetic polymorphisms involved in pathogenesies of various metabolic disorders like type 2 diabetes mellitus in different populations, however no any conclusive or even key study conducted on South Asian population especially Pakistani population except on Indian population. Worldwidle, vitamin D defeciency and type 2 diabetes mellitus (T2DM) are two interlated and most common health problems. Such interlationship is involved complex inheritance pattern.The polymorphisms of various genes including vitamin D receptor (VDR) might affect genetic susceptibility of T2DM by developing malfunctioning of beta pancreatic cells or insulin resistance. Genetic architecture of T2DM is different among various ethnic populations. The present review will focus on concept that polymorphism of VDR gene may has role in susceptibilty of onset of T2DM and its pathogenesises.
| Al-Daghri, N. M., Al-Attas, O., Alokail, M. S., Alkharfy, K. M., Draz, H. M., Agliardi, C., Mohammed, A. K., Guerini, F. R. & Clerici, M. (2012). Vitamin D receptor gene polymorphisms and HLA DRB1* 04 cosegregation in Saudi type 2 diabetes patients. The Journal of Immunology, 188, 1325-1332. Crossref |
||||
| American Diabetes Association (2015). Diabetes Care. 38(Suppl. 1), S3-S3. https://doi.org/10.2337/dc15-S002. Crossref |
||||
| Anderson, P. H., May, B. K., & Morris, H. A. (2003). Vitamin D metabolism: new concepts and clinical implications. The Clinical Biochemist Reviews, 24(1), 13-26. | ||||
| Arguelles, L. M., Langman, C. B., Ariza, A. J., Ali, F. N., Dilley, K., Price, H., Liu, X., Zhang, S., Hong, X., Wang, B., & Xing, H. (2009). Heritability and environmental factors affecting vitamin D status in rural Chinese adolescent twins. The Journal of Clinical Endocrinology and Metabolism, 94(9), 3273-3281. Crossref |
||||
| Arunabh, S., Pollack, S., Yeh, J., & Aloia, J. F. (2003). Body fat content and 25-hydroxyvitamin D levels in healthy women. The Journal of Clinical Endocrinology and Metabolism, 88(1), 157-161. Crossref |
||||
| Avenell, A., Cook, J. A., MacLennan, G. S., & McPherson, G. C. RECORD Trial Group 2009 Vitamin D supplementation and type 2 diabetes: a sub study of a randomised placebo-controlled trial in older people (RECORD Trial, ISRCTN 51647438). Age Ageing, 38, 606-609. Crossref |
||||
| Bacha, F., Saad, R., Gungor, N., & Arslanian, S. A. (2004). Adiponectin in youth: relationship to visceral adiposity, insulin sensitivity, and β-cell function. Diabetes Care, 27(2), 547-552. Crossref |
||||
| Baier, L. (1996). The Pima Diabetes Genes Group: suggestive linkage of genetic markers on chromosome 4q12 to NIDDM and insulin action in Pima Indians: new evidence to extend associations in other populations. Diabetes, 45(Suppl 2), 30A. | ||||
| Baynes, K. C. R., Boucher, B. J., Feskens, E. J. M., & Kromhout, D. (1997). Vitamin D, glucose tolerance and insulinaemia in elderly men. Diabetologia, 40(3), 344-347. Crossref |
||||
| Behall, K. M., Scholfield, D. J., Hallfrisch, J. G., Kelsay, J. L., & Reiser, S. (1984). Seasonal variation in plasma glucose and hormone levels in adult men and women. The American Journal of Clinical nutrition, 40(6), 1352-1356. Crossref |
||||
| Bethea, S. W., & Nestler, J. E. (2008). Comorbidities in polycystic ovary syndrome: their relationship to insulin resistance. Panminerva Medica, 50(4), 295-304. | ||||
| Bid, H. K., Konwar, R., Aggarwal, C. G., Gautam, S., Saxena, M., Nayak, V. L., & Banerjee, M. (2009). Vitamin D receptor (FokI, BsmI and TaqI) gene polymorphisms and type 2 diabetes mellitus: a North Indian study. Indian Journal of Medical Sciences, 63(5), 187-194. Crossref |
||||
| Bischoff, H. A., Borchers, M., Gudat, F., Duermueller, U., Theiler, R., Stähelin, H. B., & Dick, W. (2001). In situ detection of 1, 25-dihydroxyvitamin D receptor in human skeletal muscle tissue. The Histochemical Journal, 33(1), 19-24. Crossref |
||||
| Bischoff‐Ferrari, H. A., Borchers, M., Gudat, F., Dürmüller, U., Stähelin, H. B., & Dick, W. (2004). Vitamin D receptor expression in human muscle tissue decreases with age. Journal of Bone and Mineral Research, 19(2), 265-269. Crossref |
||||
| Bland, R., Markovic, D., Hills, C. E., Hughes, S. V., Chan, S. L., Squires, P. E., & Hewison, M. (2004). Expression of 25-hydroxyvitamin D3-1α-hydroxylase in pancreatic islets. The Journal of Steroid Biochemistry and Molecular Biology, 89, 121-125. Crossref |
||||
| Bloomgarden, Z. T. (1998). Insulin resistance: current concepts. Clinical Therapeutics, 20(2), 216-231. Crossref |
||||
| Blum, M., Dolnikowski, G., Seyoum, E., Harris, S. S., Booth, S. L., Peterson, J., Saltzman, E., & Dawson-Hughes, B. (2008). Vitamin D 3 in fat tissue. Endocrine, 33(1), 90-94. Crossref |
||||
| Bonora, E. (2008). Protection of pancreatic beta-cells: is it feasible? Nutrition, Metabolism and Cardiovascular Diseases, 18(1), 74-83. Crossref |
||||
| Boucher, B. J., Mannan, N., Noonan, K., Hales, C. N., & Evans, S. J. W. (1995). Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in east London Asians. Diabetologia, 38(10), 1239-1245. Crossref |
||||
| Bouillon, R., Bischoff‐Ferrari, H., & Willett, W. (2008). Vitamin D and health: perspectives from mice and man. Journal of Bone and Mineral Research, 23(7), 974-979. Crossref |
||||
| Boullu-Sanchis, S., Lepretre, F., Hedelin, G., Donnet, J. P., Schaffer, P., Froguel, P., & Pinget, M. (1999). Type 2 diabetes mellitus: association study of five candidate genes in an Indian population of Guadeloupe, genetic contribution of FABP2 polymorphism. Diabetes and Metabolism, 25(2), 150-156. | ||||
| Boyd, A. E., Hill, R. S., Oberwetter, J. M., & Berg, M. (1986). Calcium dependency and free calcium concentrations during insulin secretion in a hamster beta cell line. The Journal of Clinical Investigation, 77(3), 774-781. Crossref |
||||
| Breslau, N. A. (2008). Normal and abnormal regulation of 1, 25 (OH)2D synthesis. The American Journal of the Medical Sciences, 296(6), 417-425. Crossref |
||||
| Calvo, M. S., Whiting, S. J., & Barton, C. N. (2004). Vitamin D fortification in the United States and Canada: current status and data needs. The American Journal of Clinical Nutrition, 80(6), 1710S-1716S. Crossref |
||||
| Calvo, M. S., Whiting, S. J., & Barton, C. N. (2005). Vitamin D intake: a global perspective of current status. The Journal of Nutrition, 135(2), 310-316. Crossref |
||||
| Chiu, K. C., Chu, A., Go, V. L. W., & Saad, M. F. (2004). Hypovitaminosis D is associated with insulin resistance and β cell dysfunction. The American Journal of Clinical Nutrition, 79(5), 820-825. Crossref |
||||
| Chiu, K. C., Chuang, L. M., & Yoon, C. (2001). The vitamin D receptor polymorphism in the translation initiation codon is a risk factor for insulin resistance in glucose tolerant Caucasians. BMC Medical Genetics, 2(1), 2-3. Crossref |
||||
| Cigolini, M., Iagulli, M. P., Miconi, V., Galiotto, M., Lombardi, S., & Targher, G. (2006). Serum 25-hydroxyvitamin D3 concentrations and prevalence of cardiovascular disease among type 2 diabetic patients. Diabetes Care, 29(3), 722-724. Crossref |
||||
| Clark, S. A., Stumpf, W. E., & Sar, M. (1981). Effect of 1, 25 dihydroxyvitamin D3 on insulin secretion. Diabetes, 30(5), 382-386. Crossref |
||||
| Clemens, T. L., Henderson, S. L., Adams, J. S., & Holick, M. F. (1982). Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. The Lancet, 319(8263), 74-76. Crossref |
||||
| De Boer, I. H., Tinker, L. F., Connelly, S., Curb, J. D., Howard, B. V., Kestenbaum, B., Larson, J. C., Manson, J. E., Margolis, K. L., Siscovick, D. S., & Weiss, N. S. (2008). Calcium plus vitamin D supplementation and the risk of incident diabetes mellitus in the Women's Health Initiative. Diabetes care, 31, 701-707. Crossref |
||||
| de Lourdes Lima, M., Cruz, T., Rodrigues, L. E., Bomfim, O., Melo, J., Correia, R., Porto, M., Cedro, A., & Vicente, E. (2009). Serum and intracellular magnesium deficiency in patients with metabolic syndrome—evidences for its relation to insulin resistance. Diabetes Research and Clinical Practice, 83(2), 257-262. Crossref |
||||
| de Souza, C. J., & Meier, A. H. (1987). Circadian and seasonal variations of plasma insulin and cortisol concentrations in the Syrian hamster, Mesocricetus auratus. Chronobiology International, 4(2), 141-151. Crossref |
||||
| Del Gobbo, L. C., Song, Y., Dannenbaum, D. A., Dewailly, E., & Egeland, G. M. (2010). Serum 25-Hydroxyvitamin D Is not Associated with Insulin Resistance or Beta Cell Function in Canadian Cree, 2. The Journal of Nutrition, 141(2), 290-295. Crossref |
||||
| DeLuca, H. F. (2004). Overview of general physiologic features and functions of vitamin D. The American Journal of Clinical Nutrition, 80(6), 1689S-1696S. Crossref |
||||
| Dilmec, F., Uzer, E., Akkafa, F., Kose, E., & van Kuilenburg, A. B. (2010). Detection of VDR gene ApaI and TaqI polymorphisms in patients with type 2 diabetes mellitus using PCR-RFLP method in a Turkish population. Journal of Diabetes and its Complications, 24(3), 186-191. Crossref |
||||
| Donath, M. Y., & Shoelson, S. E. (2011). Type 2 diabetes as an inflammatory disease. Nature Reviews Immunology, 11(2), 98-107. Crossref |
||||
| Donath, M. Y., & Shoelson, S. E. (2011). Type 2 diabetes as an inflammatory disease. Nature Reviews Immunology, 11(2), 98. Crossref |
||||
| Doró, P., Benkő, R., Matuz, M., & Soós, G. (2006). Seasonality in the incidence of type 2 diabetes: a population-based study. Diabetes Care, 29(1), 173-173. Crossref |
||||
| Draznin, B. (1988). Intracellular calcium, insulin secretion, and action. The American Journal of Medicine, 85(5), 44-58. Crossref |
||||
| Draznin, B., Sussman, K., Kao, M., Lewis, D., & Sherman, N. (1987). The existence of an optimal range of cytosolic free calcium for insulin-stimulated glucose transport in rat adipocytes. Journal of Biological Chemistry, 262(30), 14385-14388. | ||||
| Fagard, R. H., & Nilsson, P. M. (2009). Smoking and diabetes—the double health hazard!. Primary Care Diabetes, 3(4), 205-209. Crossref |
||||
| Filus, A., Trzmiel, A., Kuliczkowska-Płaksej, J., Tworowska, U., Jędrzejuk, D., Milewicz, A., & Mędraś, M. (2008). Relationship between vitamin D receptor BsmI and FokI polymorphisms and anthropometric and biochemical parameters describing metabolic syndrome. The Aging Male, 11(3), 134-139. Crossref |
||||
| Fleet, J. C. (2004). Rapid, membrane-initiated actions of 1, 25 dihydroxyvitamin D: what are they and what do they mean? The Journal of Nutrition, 134(12), 3215-3218. Crossref |
||||
| Gastaldelli, A. (2011). Role of beta-cell dysfunction, ectopic fat accumulation and insulin resistance in the pathogenesis of type 2 diabetes mellitus. Diabetes Research and Clinical Practice, 93, S60-S65. Crossref |
||||
| Greenberg, A. S., & McDaniel, M. L. (2002). Identifying the links between obesity, insulin resistance and β‐cell function: potential role of adipocyte‐derived cytokines in the pathogenesis of type 2 diabetes. European Journal of Clinical Investigation, 32, 24-34. Crossref |
||||
| Grønbæk, H., Thomsen, K. L., Rungby, J., Schmitz, O., & Vilstrup, H. (2008). Role of nonalcoholic fatty liver disease in the development of insulin resistance and diabetes. Expert Review of Gastroenterology & Hepatology, 2(5), 705-711. Crossref |
||||
| Gulseth, H. L., Gjelstad, I. M., Tierney, A. C., Lovegrove, J. A., Defoort, C., Blaak, E. E., Lopez-Miranda, J., Kiec-Wilk, B., Ris, U., Roche, H. M., & Drevon, C. A. (2010). Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome. Diabetes care, 33(4), 923-925. Crossref |
||||
| Hanley, A. J., Williams, K., Gonzalez, C., D'Agostino, R. B., Wagenknecht, L. E., Stern, M. P., & Haffner, S. M. (2003). Prediction of type 2 diabetes using simple measures of insulin resistance: combined results from the San Antonio Heart Study, the Mexico City Diabetes Study, and the Insulin Resistance Atherosclerosis Study. Diabetes, 52(2), 463-469. Crossref |
||||
| Herder, C., & Roden, M. (2011). Genetics of type 2 diabetes: pathophysiologic and clinical relevance. European journal of Clinical Investigation, 41(6), 679-692. Crossref |
||||
| Hirai, M., Suzuki, S., Hinokio, Y., Chiba, M., Kasuga, S., Hirai, A., & Toyota, T. (1998). Group specific component protein genotype is associated with NIDDM in Japan. Diabetologia, 41(6), 742-743. Crossref |
||||
| Hitman, G. A., Mannan, N., McDermott, M. F., Aganna, E., Ogunkolade, B. W., Hales, C. N., & Boucher, B. J. (1998). Vitamin D receptor gene polymorphisms influence insulin secretion in Bangladeshi Asians. Diabetes, 47(4), 688-690. Crossref |
||||
| Holick, M. F. (2003). Vitamin D: A millenium perspective. Journal of Cellular Biochemistry, 88(2), 296-307. Crossref |
||||
| Holick, M. F. (2011). Vitamin D: evolutionary, physiological and health perspectives. Current Drug Targets, 12(1), 4-18. Crossref |
||||
| Holick, M. F., Chen, T. C., Lu, Z., & Sauter, E. (2007). Vitamin D and skin physiology: A D‐lightful story. Journal of Bone and Mineral Research, 22(S2), V28-V33. Crossref |
||||
| Hussain, M., Naqvi, S. B. S., Khan, M. A., Rizvi, M., Alam, S., Abbas, A., & Akram, M. U. H. A. M. M. A. D. (2014). Direct cost of treatment of diabetes mellitus type 2 in Pakistan. International Journal of Pharmacy and Pharmaceutical Sciences, 6(11), 261-4. | ||||
| Imamura, M., & Maeda, S. (2011). Genetics of type 2 diabetes: the GWAS era and future perspectives. Endocrine Journal, 58(9), 723-739. Crossref |
||||
| Ishaq, M., Khan, G. J., ur Rahman, S., & Zulfiqar, S. (2013). Prevalence of complications in type 2 diabetes mellitus patients. Pakistan Journal of Physiology, 9(2), 35-37. | ||||
| Ishimura, E., Nishizawa, Y., Inaba, M., Matsumoto, N., Emoto, M., Kawagishi, T., Shoji, S., Okuno, S., Kim, M., Miki, T., & Morii, H. (1999). Serum levels of 1, 25-dihydroxyvitamin D, 24, 25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure. Kidney International, 55(3), 1019-1027. Crossref |
||||
| Islam, M. K., Siddhika, A., Manisha, D., Akhter, S., Hassan Z., & Alis, L., (2014). Association of vitamin D receptor gene Bsm1 (A>G) and Fok1 (C>T) polymorphism in the pathogenesis of impaired glucose tolerance in Bangladeshi subjects. SMU Medical Journal, 1(1), 67-78. | ||||
| Johnson, J. A., Grande, J. P., Roche, P. C., & Kumar, R. A. J. I. V. (1994). Immunohistochemical localization of the 1, 25 (OH) 2D3 receptor and calbindin D28k in human and rat pancreas. American Journal of Physiology-Endocrinology and Metabolism, 267(3), E356-E360. Crossref |
||||
| Jorde, R., Schirmer, H., Wilsgaard, T., Joakimsen, R. M., Mathiesen, E. B., Njølstad, I., Løchen, M.L., Figenschau, Y., Berg, J.P., Svartberg, J., & Grimnes, G. (2012). Polymorphisms related to the serum 25-hydroxyvitamin D level and risk of myocardial infarction, diabetes, cancer and mortality. The Tromsø Study. PloS one, 7(5), e37295. Crossref |
||||
| Kadowaki, T., Yamauchi, T., Kubota, N., Hara, K., & Ueki, K. (2008, March). Adiponectin and adiponectin receptors in obesity-linked insulin resistance. Novartis Found Symp., 286, 164-176. | ||||
| Karohl, C., Su, S., Kumari, M., Tangpricha, V., Veledar, E., Vaccarino, V., & Raggi, P. (2010). Heritability and seasonal variability of vitamin D concentrations in male twins–. The American Journal of Clinical Nutrition, 92(6), 1393-1398. Crossref |
||||
| Kharroubi, I., Rasschaert, J., Eizirik, D. L., & Cnop, M. (2003). Expression of adiponectin receptors in pancreatic β cells. Biochemical and Biophysical Research Communications, 312(4), 1118-1122. Crossref |
||||
| Konstantinos, P., Banach, M., Bekiari, E., Rizzo M., & Edmond, M. (2017). Complications of Diabetes. Journal of Diabetes Research, vol. 2018, Article ID 3086167, 4 pages. | ||||
| Li, J., Byrne, M. E., Chang, E., Jiang, Y., Donkin, S. S., Buhman, K. K., Burgess, J. R., & Teegarden, D. (2008). 1α, 25-Dihydroxyvitamin D hydroxylase in adipocytes. The Journal of Steroid Biochemistry and Molecular Biology, 112(1-3), 122-126. Crossref |
||||
| Liel, Y., Ulmer, E., Shary, J., Hollis, B. W., & Bell, N. H. (1988). Low circulating vitamin D in obesity. Calcified Tissue International, 43(4), 199-201. Crossref |
||||
| Lo, C. W., Paris, P. W., Clemens, T. L., Nolan, J., & Holick, M. F. (1985). Vitamin D absorption in healthy subjects and in patients with intestinal malabsorption syndromes. The American journal of clinical nutrition, 42(4), 644-649. Crossref |
||||
| Maedler, K. (2008). Beta cells in type 2 diabetes–a crucial contribution to pathogenesis. Diabetes, Obesity and Metabolism, 10(5), 408-420. Crossref |
||||
| Maestro, B., Campión, J., Dávila, N., & Calle, C. (2000). Stimulation by 1, 25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocrine Journal, 47(4), 383-391. Crossref |
||||
| Maestro, B., Dávila, N., Carranza, M. C., & Calle, C. (2003). Identification of a Vitamin D response element in the human insulin receptor gene promoter. The Journal of Steroid Biochemistry and Molecular Biology, 84(2-3), 223-230. Crossref |
||||
| Malecki, M. T., Frey, J., Moczulski, D., Klupa, T., Kozek, E., & Sieradzki, J. (2003). Vitamin D receptor gene polymorphisms and association with type 2 diabetes mellitus in a Polish population. Experimental and Clinical Endocrinology & Diabetes, 111(8), 505-509. Crossref |
||||
| Marchetti, P., Del Prato, S., Lupi, R., & Del Guerra, S. (2006). The pancreatic beta-cell in human Type 2 diabetes. Nutrition, Metabolism and Cardiovascular Diseases, 16, S3-S6. Crossref |
||||
| Marchetti, P., Lupi, R., Federici, M., Marselli, L., Masini, M., Boggi, U., Del Guerra, S., Patanè, G., Piro, S., Anello, M., & Bergamini, E. (2002). Insulin secretory function is impaired in isolated human islets carrying the Gly972→ Arg IRS-1 polymorphism. Diabetes, 51(5), 1419-1424. Crossref |
||||
| Masood, Z., Mahmood, Q., & Ashraf, K. T. (2010). Vitamin D deficiency-an emerging public health problem in Pakistan. JUMDC, 1(1), 4-9. | ||||
| Masuda, S., Okano, T., Osawa, K., Shinjo, M., Suematsu, T., & Kobayashii, T. (1989). Concentrations of vitamin D-binding protein and vitamin D metabolites in plasma of patients with liver cirrhosis. Journal of Nutritional Science and Vitaminology, 35(4), 225-234. Crossref |
||||
| Matsuoka, L. Y., Ide, L., Wortsman, J., Maclaughlin, J. A., & Holick, M. F. (1987). Sunscreens suppress cutaneous vitamin D3 synthesis. The Journal of Clinical Endocrinology and Metabolism, 64(6), 1165-1168. Crossref |
||||
| Meigs, J. B. (2010). Epidemiology of type 2 diabetes and cardiovascular disease: translation from population to prevention: the Kelly West award lecture 2009. Diabetes Care, 33(8), 1865-1871. Crossref |
||||
| Nagpal, Sunil, Songqing Na, and Radhakrishnan Rathnachalam. "Noncalcemic actions of vitamin D receptor ligands." Endocrine Reviews, 26(5), 662-687. Crossref |
||||
| Norman, A. W. (2006). Vitamin D receptor: new assignments for an already busy receptor. Endocrinology, 147, 5542-5548. Crossref |
||||
| Norman, A. W. 1998. Sunlight, season, skin pigmentation, vitamin D, and 25-hydroxyvitamin D: integral components of the vitamin D endocrine system. Am. J. Clin. Nutr., 67, 1108-1110. Crossref |
||||
| Norman, A. W., Frankel, J. B., Heldt, A. M., & Grodsky, G. M. (1980). Vitamin D deficiency inhibits pancreatic secretion of insulin. Science, 209(4458), 823-825. Crossref |
||||
| Nosratabadi, R., Arababadi, M. K., Salehabad, V. A., Shamsizadeh, A., Mahmoodi, M., Sayadi, A. R., & Kennedy, D. (2010). Polymorphisms within exon 9 but not intron 8 of the vitamin D receptor are associated with the nephropathic complication of type‐2 diabetes. International Journal of Immunogenetics, 37(6), 493-497. Crossref |
||||
| Nykjaer, A., Dragun, D., Walther, D., Vorum, H., Jacobsen, C., Herz, J., Melsen, F., Christensen, E. I., & Willnow, T. E. (1999). An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell, 96(4), 507-515. Crossref |
||||
| Ogunkolade, B. W., Boucher, B. J., Prahl, J. M., Bustin, S. A., Burrin, J. M., Noonan, K., North, B. V., Mannan, N., McDermott, M. F., DeLuca, H. F., & Hitman, G. A. (2002). Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians. Diabetes, 51(7), 2294-2300. Crossref |
||||
| Oh, J. Y., & Barrett-Connor, E. (2002). Association between vitamin D receptor polymorphism and type 2 diabetes or metabolic syndrome in community-dwelling older adults: the Rancho Bernardo Study. Metabolism-Clinical and Experimental, 51(3), 356-359. Crossref |
||||
| Omdahl, J. L., Morris, H. A., & May, B. K. (2002). Hydroxylase enzymes of the vitamin D pathway: expression, function, and regulation. Annual Review of Nutrition, 22(1), 139-166. Crossref |
||||
| Orozco, L. J., Buchleitner, A. M., Gimenez-Perez, G., Roqué, I. F. M., Richter, B., & Mauricio, D. (2008). Exercise or exercise and diet for preventing type 2 diabetes mellitus. Cochrane Database Syst Rev., 3. CD003054. Crossref |
||||
| Ortlepp, J. R., Lauscher, J., Hoffmann, R., Hanrath, P., & Joost, H. G. (2001). The vitamin D receptor gene variant is associated with the prevalence of type 2 diabetes mellitus and coronary artery disease. Diabetic Medicine, 18(10), 842-845. Crossref |
||||
| Ortlepp, J. R., Metrikat, J., Albrecht, M., Von Korff, A., Hanrath, P., & Hoffmann, R. (2003). The vitamin D receptor gene variant and physical activity predicts fasting glucose levels in healthy young men. Diabetic Medicine, 20(6), 451-454. Crossref |
||||
| Orwoll, E., Riddle, M., & Prince, M. (1994). Effects of vitamin D on insulin and glucagon secretion in non-insulin-dependent diabetes mellitus. The American Journal of Clinical Nutrition, 59(5), 1083-1087. Crossref |
||||
| Pierce, M., Keen, H., & Bradley, C. (1995). Risk of diabetes in offspring of parents with non‐insulin‐dependent Diabetes. Diabetic Medicine, 12(1), 6-13. Crossref |
||||
| Pittas, A. G., Dawson-Hughes, B., Li, T., Van Dam, R. M., Willett, W. C., Manson, J. E., & Hu, F. B. (2006). Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care, 29(3), 650-656. Crossref |
||||
| Pittas, A. G., Lau, J., Hu, F. B., & Dawson-Hughes, B. (2007). The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. The Journal of Clinical Endocrinology and Metabolism, 92(6), 2017-2029. Crossref |
||||
| Reaven, G., & Tsao, P. S. (2003). Insulin resistance and compensatory hyperinsulinemia: the key player between cigarette smoking and cardiovascular disease? Journal of the American College of Cardiology, 41(6), 1044-1047. Crossref |
||||
| Rhee, S. Y., Hwang, Y. C., Chung, H. Y., & Woo, J. T. (2012). Vitamin D and diabetes in Koreans: analyses based on the Fourth Korea National Health and Nutrition Examination Survey (KNHANES), 2008–2009. Diabetic Medicine, 29(8), 1003-1010. Crossref |
||||
| Sakaki, T., Kagawa, N., Yamamoto, K., & Inouye, K. (2005). Metabolism of vitamin D3 by cytochromes P450. Frontiers in Bioscience, 10, 119-134. | ||||
| Scragg, R., Sowers, M., & Bell, C. (2004). Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care, 27(12), 2813-2818. Crossref |
||||
| Sergeev, I. N., & Rhoten, W. B. (1995). 1, 25-Dihydroxyvitamin D3 evokes oscillations of intracellular calcium in a pancreatic beta-cell line. Endocrinology, 136(7), 2852-2861. Crossref |
||||
| Sohail, M. (2014). Prevalence of Diabetic Retinopathy among Type–2 Diabetes Patients in Pakistan–Vision Registry. Pak. J. Ophthalmol., 30(4), 204-212. | ||||
| Speer, G., Cseh, K., Winkler, G., Vargha, P., Braun, E., Takacs, I., & Lakatos, P. (2001). Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity. European Journal of Endocrinology, 144(4), 385-389. Crossref |
||||
| Sreelatha, D., P. Laxmi and K. R. Amarnath. 2015. Study of liver function tests in type 2 diabetes mellitus patients. IJPRBS. 5: 39-45. | ||||
| Sreelatha, S. S., Devi, S. M., Rohini, E., and Seema, S. N. 2015. Prevalence of GDM diagnosed by DIPSI Guidelines. IJPRUR, 4, 841-844. | ||||
| Strushkevich, N., Usanov, S. A., Plotnikov, A. N., Jones, G., & Park, H. W. (2008). Structural analysis of CYP2R1 in complex with vitamin D3. Journal of Molecular Biology, 380(1), 95-106. Crossref |
||||
| Sung, C. C., Liao, M. T., Lu, K. C., & Wu, C. C. (2012). Role of vitamin D in insulin resistance. Journal of Biomedicine and Biotechnology, Volume 2012, Article ID 634195, 11 pages. doi:10.1155/2012/634195. Crossref |
||||
| Szathmary, E. J. (1987). The effect of Gc genotype on fasting insulin level in Dogrib Indians. Human Genetics, 75(4), 368-372. Crossref |
||||
| Tripkovic, L., Lambert, H., Hart, K., Smith, C. P., Bucca, G., Penson, S., Chope, G., Hyppönen, E., Berry, J., Vieth, R., & Lanham-New, S. (2012). Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. The American journal of clinical nutrition, 95(6), 1357-1364. Crossref |
||||
| Tworowska-Bardzińska, U., Lwow, F., Kubicka, E., Łaczmański, Ł., Jędzrzejuk, D., Dunajska, K., & Milewicz, A. (2008). The vitamin D receptor gene Bsm I polymorphism is not associated with anthropometric and biochemical parameters describing metabolic syndrome in postmenopausal women. Gynecological Endocrinology, 24(9), 514-518. Crossref |
||||
| Utzschneider, K. M., Carr, D. B., Hull, R. L., Kodama, K., Shofer, J. B., Retzlaff, B. M., Knopp, R. H., & Kahn, S. E. (2004). Impact of intra-abdominal fat and age on insulin sensitivity and β-cell function. Diabetes, 53(11), 2867-2872. Crossref |
||||
| van de Bunt, M., Morán, I., Ferrer, J., & McCarthy, M. I. (2014). Insights into β-Cell Biology and Type 2 Diabetes Pathogenesis from Studies of the Islet Transcriptome. In Genetics in Diabetes, 23, 111-121. Crossref |
||||
| Vieth, R. (2009). How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology. Anticancer Research, 29(9), 3675-3684. | ||||
| Vural, H. C., & Maltas, E. (2012). RT-qPCR assay on the vitamin D receptor gene in type 2 diabetes and hypertension patients in Turkey. Genet Mol Res., 11(1), 582-590. Crossref |
||||
| Wheeler, E., & Barroso, I. (2011). Genome-wide association studies and type 2 diabetes. Briefings in functional genomics, 10(2), 52-60. Crossref |
||||
| Worrall, D. S., & Olefsky, J. M. (2002). The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes. Molecular Endocrinology, 16(2), 378-389. Crossref |
||||
| Wortsman, J., Matsuoka, L. Y., Chen, T. C., Lu, Z., & Holick, M. F. (2000). Decreased bioavailability of vitamin D in obesity. The American Journal of Clinical Nutrition, 72(3), 690-693. Crossref |
||||
| Wu, T., Willett, W. C., & Giovannucci, E. (2009). Plasma C-peptide is inversely associated with calcium intake in women and with plasma 25-hydroxy vitamin D in men. The Journal of Nutrition, 139(3), 547-554. Crossref |
||||
| Ye, W. Z., Reis, A. F., Dubois-Laforgue, D., Bellanne-Chantelot, C., Timsit, J., & Velho, G. (2001). Vitamin D receptor gene polymorphisms are associated with obesity in type 2 diabetic subjects with early age of onset. European Journal of Endocrinology, 145(2), 181-186. Crossref |
||||
| Zanuso, S., Jimenez, A., Pugliese, G., Corigliano, G., & Balducci, S. (2010). Exercise for the management of type 2 diabetes: a review of the evidence. Acta Diabetologica, 47(1), 15-22. Crossref |
||||
| Zeitz, U., Weber, K., Soegiarto, D. W., Wolf, E., Balling, R., & Erben, R. G. (2003). Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor. The FASEB Journal, 17(3), 509-511. Crossref |
||||
| Zheng, Y., Ley, S. H., & Hu, F. B. (2018). Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nature Reviews Endocrinology, 14(2), 88. Crossref |
||||
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