JOURNAL OF ANIMAL SCIENCE AND VETERINARY MEDICINE
Integrity Research Journals
ISSN: 2536-7099
Model: Open Access/Peer Reviewed
DOI: 10.31248/JASVM
Start Year: 2016
Email: jasvm@integrityresjournals.org
Effect of nickel chloride on reproductive parameters and testicular oxidative stress biomarkers in male guinea pigs
https://doi.org/10.31248/JASVM2021.265 | Article Number: D74EA5962 | Vol.6 (3) - June 2021
Received Date: 26 April 2021 | Accepted Date: 21 May 2021 | Published Date: 30 June 2021
Authors: Yidjeu Nana Aristide* , Nantia Akono Edouard , Tchagnhe Fotsing Milwilie , Guiekep Nounamo Jemima , Vemo Narcisse Bertin and Kenfack Augustave
Keywords: male guinea pig, oxidative stress, nickel chloride, reproductive toxicity.
The soil and agricultural products pollution by nickel represents an important public health risk in agrarian areas such as the Dschang in Cameroon. This study was designed to evaluate the reproductive toxicity and oxidative stress potential of nickel chloride in male guinea pig. Four groups of adult male guinea pigs were orally treated with nickel chloride at doses of 0, 17.50, 26.25 and 52.50 mg/kg bw for 90 days. At the end of the experimental period, all animals were sacrificed, and blood samples and vital organs were collected for different analysis. Treatment of male guinea pigs with 52.50 mg/kg nickel chloride resulted in increased kidney weight and volume and decreased weights of the sex accessory glands (seminal vesicle + prostate + coagulating glands), epididymis and vas deferens. The 52.50 mg/kg dose of nickel chloride decreased (p<0.05) the animal’s sperm mobility, number and viability, while it increased (p<0.05) sperm micro and macrocephalies. Assessment of biochemical parameters of toxicity revealed increase (p<0.05) of serum creatinine and aminotransferases activities in the nickel chloride-exposed guinea pigs (52.50 mg/kg). The nickel chloride (52.50 mg/kg) also promoted oxidative stress, through decrease (p<0.05) of superoxide dismutase and catalase activities, as well as increase (p<0.05) in lipid peroxydation. In addition, histology of testis revealed disrupted germ cell arrangement, decreased concentration of sperms in the lumen of the seminiferous tubules and degraded germinal epithelium in the animals exposed to nickel chloride. In conclusion, results obtained in this study revealed that nickel chloride perturbs male reproductive system and induced oxidative stress.
| Aelion, C., Davis, H., McDermott, S., & Lawson, A. (2008). Metal concentrations in rural topsoil in South Carolina: potential for human health impact. Science of the Total Environment, 402 (2-3), 149-156. Crossref |
||||
| Amudha, K., & Pari, L. (2011). Beneficial role of naringin, a flavanoid on nickel induced nephrotoxicity in rats. Chemico- Crossref |
||||
| Das, K. K. (2009). A comprehensive review on nickel (II) and chromium (VI) toxicities - possible antioxidant (Allium Sativum Linn) defences. Al Ameen Journal of Medical Sciences, 2(2), 43-50. | ||||
| Das, K. K., & Dasgupta, S. (2002). Effect of Nickel on Testicular Nucleic Acid Concentrations of Rats on Protein Restriction. Biological Trace Element Research, 73(2):175-80. Crossref |
||||
| De Miguel, E., De Grado, M. J., Llamas, J. F., Martın-Dorado, A., & Mazadiego, L. F. (1998). The overlooked contribution of compost application to the trace element load in the urban soil of Madrid (Spain). Science of the Total Environment, 215(1-2), 113-122. Crossref |
||||
| Djemli, S., Zine, K., & Mohamed, R. (2012). Combined protective effect of zinc and vitamin C on nickel-induced oxidative liver injury in rats. Annals of Biological Research. 3(7), 3410-3418. | ||||
| Emile, M., Fernand, T., Jules, L., Nathalie, M., Gilbert, Z., & Mama, M. (2017). Chemical composition and voluntary intake of fresh forages fed to domestics' Guinea pigs (Cavia porcellus) in Western Highland of Cameroun. Austin Journal of Aquaculture and Marine Biology, 2(1), 1006. | ||||
| Garrido, N., Meseguer, M., Simon, C., Pellicer, A., & Remohi, J. (2004). Pro-oxidative and anti-oxidative imbalance in human semen and its relation with male fertility. Asian Journal Andrology, 6(1), 59-65. | ||||
| Hu, W., Yu, Z., Gao, X., Wu, Y., Tang, M., & Kong, L. (2020). Study on the damage of sperm induced by nickel nanoparticle exposure. Environmental Geochemistry and Health, 42(6), 1715-1724. Crossref |
||||
| Jordan, C. L., & DonCarlos, L. (2008). Androgens in health and disease: an overview. Hormones and behavior, 53(5), 589-595. Crossref |
||||
| Kadiand, I-E., & Dahdouh, F. (2016). Vitamin C pretreatment protects from nickel-induced acute nephrotoxicity in mice. Arhiv za Higijenu rada i Toksikologiju, 67(3), 210-215. Crossref |
||||
| Kenfack, A., Guiekep, A., Ngoula, F., Vemo, B., Bouli, F., & Pamo, E. (2018). Reproductive toxicity of acetamiprid in male Guinea pig (Cavia porcellus). Journal of Animal Science and Veterinary Medicine, 3(4), 105-111. Crossref |
||||
| Knazicka, Z., Forgacs, Z., Lukacova, J., Roychoudhury, S., Massanyi, P., & Lukac, N. (2015). Endocrine disruptive effects of cadmium on steroidogenesis: human adrenocortical carcinoma cell line NCI-H295R as a cellular model for reproductive toxicity testing. Journal of Environmental Science and Health, Part A, 50(4), 348-356. Crossref |
||||
| Kodjio, N., Atsafack, S., Njateng, G., Sokoudjou, J., Kuiate, J., & Gatsing, G. (2016). Antioxidant effect of aqueous extract of Curcuma longa rhizomes (Zingiberaceae) in the typhoid fever induced in Wistar rats model. Journal of Advances in Medical and Pharmaceutical Sciences, 7(3), 1-13. Crossref |
||||
| Lu, K., Meng, T., Ting, Z., Dayong, W., Ke, H., Weiqi, L., Chao, W., Geyu, L., & Yuepu, P. (2014). Nickel nanoparticles exposure and reproductive toxicity in healthy adult rats. International Journal of Molecular Sciences, 15(11), 21253-21269. Crossref |
||||
| Lum, A., Ngwa, E., Chikoye, D., & Suh, C. (2014). Phytoremediation potential of weeds in heavy metal contaminated soils of the Bassa Industrial Zone of Douala, Cameroon. International Journal Phytoremediation, 16(3), 302-19. Crossref |
||||
| Manfo, T., Akono, N., Kai-Lee, W., Moundipa, F., & Mathur, P. (2014). Heavy metal induced toxicity on male reproductive function. Contemporary Topics in Life Sciences, Pp. 1-26. | ||||
| Massanyi, P., Trandzik, J., Nad, P., Korenekova, B., Skalicka, M., Toman, R., Lukac, N., Halo, M., & Strapak, P. (2004). Concentration of copper, iron, zinc, cadmium, lead, and nickel in bull and ram semen and relation to the occurrence of pathological spermatozoa. Journal of Environmental Science and Health, 39(11-12), 3005-3014. Crossref |
||||
| Mathur, P., Huang, L., Kashou, A., Vaithinathan, S., & Agarwal, A. (2011). Environmental toxicants and testicular apoptosis. The Open Reproductive Science Journal, 3, 114-124. Crossref |
||||
| Misra, H. P., & Fridovich, I. (1972). The generation of superoxide radical during the autoxidation of hemoglobin. Journal of Biological Chemistry, 247(21), 6960-6962. Crossref |
||||
| Motofei, I., & Rowland, D. (2005). The physiological basis of human sexual arousal: neuroendocrine sexual asymmetry. International Journal of Andrology, 28(2), 78-87. Crossref |
||||
| Nilsson, U., Olsson, L., Carlin, G., & Bylund-Fellenius, A. (1989). Inhibition of lipid peroxidation by spin labels. Relationships between structure and function. Journal Biological Chemistry, 264(19), 11131-11135. Crossref |
||||
| Noubissié, E., Ngassoum, M. B., Ali, A., Castro-Georgi, J., & Donard, O. F. (2016). Contamination of market garden soils by metals (Hg, Sn, Pb) and risk for vegetable consumers of Ngaoundéré (Cameroon). Euro-Mediterranean Journal for Environmental Integration, 1, Article number 9. Crossref |
||||
| Oluyomi, S., Sokolayemji, A., & Adewumi, A. (2017). Moringa oleifera-based diet protects against nickel-induced hepatotoxicity in rats. Journal Biomedical Research, 31(4), 350-357. | ||||
| Pamo, T., Tankou, C., Kamga, A., & Kengni, L. (2003). Introduction à la vulgarisation des pratiques de l'intégration de l'agriculture et de l'élevage par l'utilisation des plantes agroforestières au Cameroun. Deuxième édition AIEA/Université de Dschang. pp. 84. | ||||
| Pandey, R., Kumar, R., Singh, S., Saxena, D., & Srivastava, S. (1999). Male reproductive effect of nickel sulphate in mice. Biometals, 12(4), 339-46. Crossref |
||||
| Payne, A. H., & Hales, D. B. (2004). Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocrine Reviews, 25(6), 947-970. Crossref |
||||
| Pham-Huy, L., He, H., & Pham-Huy, C. (2008). Free radicals, antioxidants in disease and health. International Journal Biomedical Science, 4(2), 89-96. | ||||
| Prasad, A. S. (1976). Trace elements in human health and disease, Vol I. Essential and Toxic Elements. New York, Academic Press. Pp. 379-387. | ||||
| Salah, E., Ashraf, M., & Nermeen, E. (2015). Studies on the potential protective effect of curcumin and zinc against nickel- induced nephrotoxicity in rats. Journal of Current Veterinary Research, 9(1), 114-131. Crossref |
||||
| Saroj, C., & Chengjiang, B. (1999). Role of oxidative stress in nickel chloride-induced cell injury in rat renal cortical slices. Biochemical Pharmacology, 58(9), 1501-1510. Crossref |
||||
| Sinha, A. K. (1972). Colorimetric assay of catalase. Analytical Biochemistry, 47(2), 389-394. Crossref |
||||
| Temgoua, E., Ntangmo T., & Njine, T. (2012). Vegetable production systems of swamps zone in urban environment in West Cameroon: case of Dschang city. Universal Journal of Environmental Research and Technology, 2(2), 83-92. | ||||
| Temgoua, E., Ntangmo, T., Pfeifer, H., & Njine, T. (2015). Teneurs en éléments majeurs et oligoéléments dans un sol et quelques cultures maraîchères de la ville de dschang, cameroun. African Crop Science Journal, 23(1), 35-44. | ||||
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