JOURNAL OF ANIMAL SCIENCE AND VETERINARY MEDICINE
Integrity Research Journals
ISSN: 2536-7099
Model: Open Access/Peer Reviewed
DOI: 10.31248/JASVM
Start Year: 2016
Email: jasvm@integrityresjournals.org
Evaluation of some selected nutraceuticals (King-Herbs oral solution® Gumbo ND® and Grand Humi Vet®) with Gumboro vaccine for preventing experimental Gumboro disease in broilers
https://doi.org/10.31248/JASVM2026.637 | Article Number: 4409E99C3 | Vol.11 (2) - April 2026
Received Date: 02 February 2026 | Accepted Date: 25 February 2026 | Published Date: 30 April 2026
Authors: Godwin Joseph* , Bulus Gwimi , Sheriff O. Ajeigbe and Musa Zakariah
Keywords: Infectious bursal disease (IBD), Very virulent IBD virus (vvIBDV), Nutraceuticals, Gumboro vaccine and Broiler chickens.
Infectious bursal disease (IBD) is a highly contagious and immunosuppressive viral disease of chickens that causes significant economic losses in poultry production. This study assessed the prophylactic efficacy of three nutraceuticals—King-Herbs Oral Solution®, Gumbo ND®, and Grand HumiVet®—administered alone or in combination with an intermediate Gumboro vaccine in broiler chickens experimentally challenged with a very virulent IBD virus (vvIBDV). A total of 240-day-old Cobb500 broilers were randomly allocated into 12 groups (20 birds/group). Group A served as the negative control, while Group B was the positive control challenged with vvIBDV. Groups C1–C3 received individual nutraceuticals combined with vaccination and vvIBDV challenge. Groups D1–D3 received nutraceuticals without vaccination but were challenged. Groups E1–E3 received nutraceuticals only, while Group F was vaccinated and challenged without nutraceutical supplementation. Nutraceuticals were administered via drinking water from day 5 to day 28. The intermediate Gumboro vaccine was given on days 11 and 22, and the vvIBDV challenge was performed orally on day 29. Clinical signs, cloacal temperature, body weight, and mortality were monitored between 3 and 7 days post-infection (dpi). Bursa of Fabricius samples were collected at 21, 28, 35, and 42 days of age for gross and histopathological evaluation. Birds in the positive control group showed severe clinical signs, elevated cloacal temperatures, reduced body weight, and marked bursal lesions. Nutraceutical–vaccine combinations (C1–C3) provided the highest level of protection, evidenced by minimal clinical signs, improved growth performance, and significantly lower lesion scores. Nutraceutical-only groups showed partial protection, while vaccinated controls exhibited moderate resistance. Overall, supplementation with King-Herbs Oral Solution®, Gumbo ND®, or Grand HumiVet® enhanced vaccine efficacy and reduced the pathological effects of vvIBDV, suggesting their value as adjuncts in IBD control programs.
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