JOURNAL OF ANIMAL SCIENCE AND VETERINARY MEDICINE
Integrity Research Journals
ISSN: 2536-7099
Model: Open Access/Peer Reviewed
DOI: 10.31248/JASVM
Start Year: 2016
Email: jasvm@integrityresjournals.org
Serum protein modulation following jugular low-level laser therapy: Case Reports
https://doi.org/10.31248/JASVM2025.602 | Article Number: 1A0B5A494 | Vol.10 (5) - October 2025
Received Date: 13 September 2025 | Accepted Date: 15 October 2025 | Published Date: 30 October 2025
Authors: Travis Sammons* and Iliana Sosa Teste, PhD
Keywords: Beagle dogs, Ehrlichiosis, low-level laser therapy, serum protein.
This case series examined the effects of jugular-applied low-level laser therapy (LLLT) on serum protein profiles in two adult Beagle dogs with chronic Ehrlichiosis. Each received 15-minute sessions of coherent 640 nm LLLT over the jugular vein. Dog 1 for three days and Dog 2 for five days. Serum total protein, albumin, and globulin were measured before and after treatment. Both dogs showed decreased total protein and globulin levels with concurrent increases in albumin, indicating improved systemic protein balance. The composite Directional Improvement Index showed 27% improvement in Dog 1 and 49% in Dog 2, suggesting jugular LLLT may help restore protein metabolism and modulate inflammation in chronic infection.
| Blanco-Prieto, O., Catalán, J., Trujillo-Rojas, L., Peña, A., Rivera del Álamo, M. M., Llavanera, M., Bonet, S., Fernández-Novell, J.M., Yeste, M., & Rodríguez-Gil, J. E. (2020). Red LED Light acts on the mitochondrial electron chain of mammalian sperm via light-time exposure-dependent mechanisms. Cells, 9(12), 2546. https://doi.org/10.3390/cells9122546 |
||||
| Hashash, J. G., Koutroumpakis, F., Anderson, A. M., Rivers, C. R., Hosni, M., Koutroubakis, I. E., Ahsan, M., Gkiaouraki, E., Dunn, M. A., Schwartz, M., & Binion, D. G. (2022). Elevated serum globulin fraction as a biomarker of multiyear disease severity in inflammatory bowel disease. Annals of Gastroenterology, 35(6), 609. https://doi.org/10.20524/aog.2022.0748 |
||||
| Jeffery, U., Deitz, K., & Hostetter, S. (2012). Positive predictive value of albumin: globulin ratio for feline infectious peritonitis in a mid-western referral hospital population. Journal of Feline Medicine and Surgery, 14(12), 903-905. https://doi.org/10.1177/1098612X12454862 |
||||
| Peplow, P. V., Chung, T. Y., Ryan, B., & Baxter, G. D. (2011). Laser photobiomodulation of gene expression and release of growth factors and cytokines from cells in culture: a review of human and animal studies. Photomedicine and Laser Surgery, 29(5), 285-304. https://doi.org/10.1089/pho.2010.2846 |
||||
| Rola, P., Włodarczak, S., Lesiak, M., Doroszko, A., & Włodarczak, A. (2022, July). Changes in cell biology under the influence of low-level laser therapy. In Photonics (Vol. 9, No. 7, p. 502). MDPI. https://doi.org/10.3390/photonics9070502 |
||||
| Soeters, P. B., Wolfe, R. R., & Shenkin, A. (2019). Hypoalbuminemia: pathogenesis and clinical significance. Journal of Parenteral and Enteral Nutrition, 43(2), 181-193. https://doi.org/10.1002/jpen.1451 |
||||
| Sun, L., Yin, H., Liu, M., Xu, G., Zhou, X., Ge, P., Yang, H., & Mao, Y. (2019). Impaired albumin function: a novel potential indicator for liver function damage? Annals of medicine, 51(7-8), 333-344. https://doi.org/10.1080/07853890.2019.1693056 |
||||
| Trumpff, C., Michelson, J., Lagranha, C. J., Taleon, V., Karan, K. R., Sturm, G., Lindqvist, D., Fernström, J., Moser, D., Kaufman, B. A., & Picard, M. (2021). Stress and circulating cell-free mitochondrial DNA: A systematic review of human studies, physiological considerations, and technical recommendations. Mitochondrion, 59, 225-245. https://doi.org/10.1016/j.mito.2021.04.002 |
||||
| Wang, Y., Li, C., Wang, W., Wang, J., Li, J., Qian, S., Cai, C., & Liu, Y. (2022). Serum albumin to globulin ratio is associated with the presence and severity of inflammatory bowel disease. Journal of Inflammation Research, 15, 1907-1920. https://doi.org/10.2147/JIR.S347161 |
||||
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