JOURNAL OF ANIMAL SCIENCE AND VETERINARY MEDICINE
Integrity Research Journals
ISSN: 2536-7099
Model: Open Access/Peer Reviewed
DOI: 10.31248/JASVM
Start Year: 2016
Email: jasvm@integrityresjournals.org
Acute phase proteins in veterinary medicine: A review
https://doi.org/10.31248/JASVM2020.216 | Article Number: 0FB3BD8B1 | Vol.6 (6) - December 2021
Received Date: 20 July 2020 | Accepted Date: 30 October 2021 | Published Date: 30 December 2021
Author: Mahdi Ali Abdullah
Keywords: protein, Acute, animals, human
The acute phase proteins (APPs) are a group of blood proteins that contribute to restoring homeostasis and limiting microbial growth in an antibody-independent manner in animals which are exposed to different pathological conditions like infection, inflammation, surgical trauma and stress. In the last two decades, many advances have been made in monitoring APPs in both farm and companion animals for clinical and experimental purposes. Also, the mechanism of the APPs response is receiving attention in veterinary science in connection with the innate immune systems of animals. This review describes the many of new results of research and role APPs in farm animal, with special reference to their functions, types, induction and regulatory expression, some of biological functions, and their current and future applications to veterinary diagnosis and animal production.
| Abbas, A. K., Lichtman, A. H., & Pillai, S. (2012). Basic immunology: Functions and disorders of the immune system (4th edition). Elsevier Health Sciences, Philadelphia, PA. p. 40. | ||||
| Baybutt, H. N., & Holsboer, F. (1990). Inhibition of macrophage differentiation and function by cortisol. Endocrinology, 127(1), 476-480. Crossref |
||||
| Ceciliani, F., Ceron, J. J., Eckersall, P. D., & Sauerwein, H. (2012). Acute phase proteins in ruminants. Journal of proteomics, 75(14), 4207-4231. Crossref |
||||
| Ceciliani, F., Giordano, A., & Spagnolo, V. (2002). The systemic reaction during inflammation: the acute-phase proteins. Protein and Peptide Letters, 9(3), 211-223. Crossref |
||||
| Cerón, J. J., Eckersall, P. D., & Martínez‐Subiela, S. (2005). Acute phase proteins in dogs and cats: current knowledge and future perspectives. Veterinary Clinical Pathology, 34(2), 85-99. Crossref |
||||
| Chan, J. P. W., Chang, C. C., Hsu, W. L., Liu, W. B., & Chen, T. H. (2010). Association of increased serum acute‐phase protein concentrations with reproductive performance in dairy cows with postpartum metritis. Veterinary Clinical Pathology, 39(1), 72-78. Crossref |
||||
| Cray, C., Zaias, J., & Altman, N. H. (2009). Acute phase response in animals: a review. Comparative Medicine, 59(6), 517-526. | ||||
| Davidson, J. S. (2013). Inflammation and acute phase proteins in haemostasis. Acute phase proteins. Link |
||||
| Eckersall, P. D., & Bell, R. (2010). Acute phase proteins: Biomarkers of infection and inflammation in veterinary medicine. The Veterinary Journal, 185(1), 23-27. Crossref |
||||
| Eckersall, P. D., Lawson, F. P., Bence, L., Waterston, M. M., Lang, T. L., Donachie, W., & Fontaine, M. C. (2007). Acute phase protein response in an experimental model of ovine caseous lymphadenitis. BMC Veterinary Research, 3, Article number 35. Crossref |
||||
| Gabay, C., & Kushner, I. (1999). Acute-phase proteins and other systemic responses to inflammation. New England Journal of Medicine, 340(6), 448-454. Crossref |
||||
| Gómez-Laguna, J., Salguero, F. J., Pallarés, F. J., Rodríguez-Gómez, I. M., Barranco, I., & Carrasco, L. (2011). Acute phase proteins as biomarkers in animal health and welfare. In: Veas, F. (ed.). Acute phase proteins as early non-specific biomarkers of human and veterinary diseases (pp. 259-298). InTech. Crossref |
||||
| Gruys, E., Toussaint, M. J. M., Niewold, T. A., & Koopmans, S. J. (2005). Acute phase reaction and acute phase proteins. Journal of Zhejiang University Science B, 6(11), 1045-1056. Crossref |
||||
| Gutiérrez, A. M., Martínez-Subiela, S., Eckersall, P. D., & Cerón, J. J. (2009). C-reactive protein quantification in porcine saliva: a minimally invasive test for pig health monitoring. The Veterinary Journal, 181(3), 261-265. Crossref |
||||
| Heinrich, P. C., Castell, J. V., & Andus, T. (1990). Interleukin-6 and the acute phase response. Biochemical journal, 265(3), 621-636. Crossref |
||||
| Ingenbleek, Y., & Young, V. (1994). Transthyretin (prealbumin) in health and disease: nutritional implications. Annual Review of Nutrition, 14(1), 495-533. Crossref |
||||
| Jain, S., Gautam, V., & Naseem, S. (2011). Acute-phase proteins: As diagnostic tool. Journal of Pharmacy and Bioallied Sciences, 3(1), 118-127. Crossref |
||||
| Khan, F. A., & Khan, M. F. (2010). Inflammation and acute phase response. International Journal of Applied Biology and Pharmaceutical Technology, 1(2), 312-321. | ||||
| Kushner, I. (1982). The phenomenon of the acute phase response. Annals of the New York Academy of Sciences, 389, 39-48. Crossref |
||||
| Murata, H., Shimada, N., & Yoshioka, M. (2004). Current research on acute phase proteins in veterinary diagnosis: an overview. The Veterinary Journal, 168(1), 28-40. Crossref |
||||
| Nazifi, S., Tabande, M. R., Hosseinian, S. A., Ansari-Lari, M., & Safari, H. (2011). Evaluation of sialic acid and acute-phase proteins (haptoglobin and serum amyloids A) in healthy and avian infection bronchitis virus-infected chicks. Comparative Clinical Pathology, 20(1), 69-73. Crossref |
||||
| O'Reilly, E. L., & Eckersall, P. D. (2014). Acute phase proteins: a review of their function, behaviour and measurement in chickens. World's Poultry Science Journal, 70(1), 27-44. Crossref |
||||
| Orro, T., Pohjanvirta, T., Rikula, U., Huovilainen, A., Alasuutari, S., Sihvonen, L., Pelkonen, S., & Soveri, T. (2011). Acute phase protein changes in calves during an outbreak of respiratory disease caused by bovine respiratory syncytial virus. Comparative immunology, microbiology and infectious diseases, 34(1), 23-29. Crossref |
||||
| Parra, M. D., Tecles, F., Subiela, S. M., & Cerón, J. J. (2005). C-reactive protein measurement in canine saliva. Journal of Veterinary Diagnostic Investigation, 17(2), 139-144. Crossref |
||||
| Petersen, H. H., Nielsen, J. P., & Heegaard, P. M. H. (2004). Application of acute phase protein measurements in veterinary clinical chemistry. Veterinary Research, 35(2), 163-187. Crossref |
||||
| Tirziu, E. (2009). Acute-phase proteins in immune response. Lucrări Ştiinţifice Medicină Veterinară, 42(1), 329-339. | ||||
| Tóthová, C., Nagy, O., Kovac, G., & Janciauskiene, S. (2013). The use of acute phase proteins as biomarkers of diseases in cattle and swine. Acute Phase Proteins. Pp. 103-136. Crossref |
||||
| Tothova, C., Nagy, O., Seidel, H., & Kováč, G. (2011). Acute phase proteins as markers of diseases in farm animals. In: Veas, F. (ed.). Acute phase proteins as early non-specific biomarkers of human and veterinary diseases (pp. 231-258). InTech. Crossref |
||||
| Uhlar, C. M., & Whitehead, A. S. (1999). Serum amyloid A, the major vertebrate acute‐phase reactant. European Journal of Biochemistry, 265(2), 501-523. Crossref |
||||
| Veas, F. (2011). Acute phase proteins as early non-specific biomarkers of human and veterinary diseases. Janeza Trdine 9, 51000 Rijeka, Croatia. Pp. 231- 259 Crossref |
||||
| Wilson, C. R., Regnier, F. E., Knapp, D. W., Raskin, R. E., Andrews, D. A., & Hooser, S. B. (2008). Glycoproteomic profiling of serum peptides in canine lymphoma and transitional cell carcinoma. Veterinary and Comparative Oncology, 6(3), 171-181. Crossref |
||||
| Yoshioka, M., Watanabe, A., Shimada, N., Murata, H., Yokomizo, Y., & Nakajima, Y. (2002). Regulation of haptoglobin secretion by recombinant bovine cytokines in primary cultured bovine hepatocytes. Domestic Animal Endocrinology, 23(3), 425-433. Crossref |
||||
Copyright © 2026 Integrity Research Journals. All rights reserved.