JOURNAL OF BIOSCIENCE AND BIOTECHNOLOGY DISCOVERY
Integrity Research Journals
ISSN: 2536-7064
Model: Open Access/Peer Reviewed
DOI: 10.31248/JBBD
Start Year: 2016
Email: jbbd@integrityresjournals.org
Lycopene and health: From antioxidant properties to disease prevention
https://doi.org/10.31248/JBBD2025.243 | Article Number: BE4444331 | Vol.10 (5) - December 2025
Received Date: 14 November 2025 | Accepted Date: 15 December 2025 | Published Date: 30 December 2025
Authors: Muhammad Salihu Ibrahim* , Rumanatu Ibrahim Baba , Maryam Habeeb Muhammad3 , Abubakar Usman Zage and Mas’ud Abubakar
Keywords: oxidative stress, antioxidant, carotenoids, human health, chronic disease prevention, lycopene
Lycopene, a non-provitamin A carotenoid predominantly found in tomatoes and other red fruits, has emerged as a bioactive compound of considerable interest due to its potent antioxidant and anti-inflammatory properties. Recognized as one of the most effective singlet oxygen quenchers among dietary carotenoids, lycopene plays a central role in mitigating oxidative stress and preserving cellular integrity. A growing body of experimental and epidemiological evidence suggests that lycopene intake is inversely associated with the risk of several chronic diseases, including cardiovascular disorders, certain cancers, metabolic syndromes, and neurodegenerative conditions. These protective effects are primarily attributed to lycopene’s ability to neutralize reactive oxygen species, modulate inflammatory mediators, regulate gene expression, and enhance intercellular communication. Additionally, factors such as dietary composition, food processing, and individual metabolic variations significantly influence lycopene’s bioavailability and physiological efficacy. This review synthesizes current findings on the mechanistic pathways through which lycopene exerts its health-promoting effects, emphasizing its antioxidant and anti-inflammatory roles as pivotal mechanisms in disease prevention. Understanding these molecular interactions not only strengthens the evidence for lycopene’s functional relevance in human health but also underscores its potential application in nutrition-based therapeutic strategies aimed at reducing the global burden of chronic diseases.
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