JOURNAL OF BIOSCIENCE AND BIOTECHNOLOGY DISCOVERY
Integrity Research Journals

ISSN: 2536-7064
Model: Open Access/Peer Reviewed
DOI: 10.31248/JBBD
Start Year: 2016
Email: jbbd@integrityresjournals.org


Review of the correlation between pesticide uses and human chronic diseases

https://doi.org/10.31248/JBBD2024.217   |   Article Number: 1646E5D33   |   Vol.9 (3) - August 2024

Received Date: 13 July 2024   |   Accepted Date: 27 August 2024  |   Published Date: 30 August 2024

Authors:  Funsho Kolapo* , Cosmos Amankwah , Ogechi Judith Madukwe , Odemona, Ebenezer Temitope and Ololade Sophiat Alaran

Keywords: pesticides, pests, Environmental impact, Chronic diseases, human health

A pest is every living thing, that has a detrimental effect on people or their interests. They can transmit diseases, harm crops, and interfere with daily activities. Pests like rats and insects are often found in human environments. Pesticides are biological or chemical substances designed to resist, attract, control, or prevent any biological entity that is deemed a pest. Pesticides have various advantages but are also associated with several environmental and public health challenges. The review thoroughly analyzes the body of research on pesticide usage, including its categorization, historical background, impacts on human health as well as how they affect surroundings and also capture the resistance development. Understanding the link between pesticide usage and chronic diseases including Parkinson's disease, diabetes, cancer, and neurological problems is necessary to develop practical strategies for reducing these chronic diseases. The review examines the correlation between exposure to pesticides and chronic diseases and management exposure reduction techniques which include integrated pest management, sustainable agriculture, stringent pesticide regulation, public awareness campaigns, and the right use of personal protective are techniques discussed. Implementing these techniques would drastically mitigate the adverse effects of chronic diseases among people while ensuring the use of pesticides.

Abubakar, Y., Tijjani, H., Egbuna, C., Adetunji, C. O., Kala, S., Kryeziu, T. L., Ifemeje, J. C., & Patrick-Iwuanyanwu, K. C. (2020). Pesticides, history, and classification. In Natural remedies for pest, disease and weed control (pp. 29-42). Academic Press.
https://doi.org/10.1016/B978-0-12-819304-4.00003-8
 
Ahlborg, U. G., Lipworth, L., Titus-Ernstoff, L., Hsieh, C. C., Hanberg, A., Baron, J., Trichopoulos, D. & Adami, H. O. (1995). Organochlorine compounds in relation to breast cancer, endometrial cancer, and endometriosis: an assessment of the biological and epidemiological evidence. Critical Reviews in Toxicology, 25(6), 463-531.
https://doi.org/10.3109/10408449509017924
 
Ahmad, M. F., Ahmad, F. A., Alsayegh, A. A., Zeyaullah, M., AlShahrani, A. M., Muzammil, K., Saati, A. A., Wahab, S., Elbendary, E. Y., Kambal, N., & Hussain, S. (2024). Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures. Heliyon. 10, e29128
https://doi.org/10.1016/j.heliyon.2024.e29128
 
Ahmadipour, H., & Nakhei, Z. (2024). The effect of education on safe use of pesticides based on the health belief model. BMC research notes, 17, Article number 134.
https://doi.org/10.1186/s13104-024-06797-6
 
Aktar, W., Sengupta, D., & Chowdhury, A. (2009). Impact of pesticides use in agriculture: their benefits and hazards. Interdisciplinary Toxicology, 2(1), 1-12.
https://doi.org/10.2478/v10102-009-0001-7
 
Applicator Core (n.d). Chapter 7: Integrated Pest Management. Retrieved from https://www.gov.nl.ca/ecc/files/env-protection-pesticides-business-manuals-applic-chapter7.pdf.
 
Areo, O. M., Olowoyo, J. O., Sethoga, L. S., Adebo, O. A., & Njobeh, P. B. (2022). Determination of pesticide residues in rooibos (Aspalathus linearis) teas in South Africa. Toxicology Reports, 9, 852-857.
https://doi.org/10.1016/j.toxrep.2022.04.001
 
Arunrat, N., Sereenonchai, S., & Hatano, R. (2022). Effects of fire on soil organic carbon, soil total nitrogen, and soil properties under rotational shifting cultivation in northern Thailand. Journal of environmental management, 302, 113978.
https://doi.org/10.1016/j.jenvman.2021.113978
 
Asghar, U., Malik, M. F., & Javed, A. (2016). Pesticide exposure and human health: a review. J Ecosys Ecograph S: 005.
 
Band, P. R., Abanto, Z., Bert, J., Lang, B., Fang, R., Gallagher, R. P., & Le, N. D. (2011). Prostate cancer risk and exposure to pesticides in British Columbia farmers. The Prostate, 71(2), 168-183.
https://doi.org/10.1002/pros.21232
 
Bassil, K. L., Vakil, C., Sanborn, M., Cole, D. C., Kaur, J. S., & Kerr, K. J. (2007). Cancer health effects of pesticides: systematic review. Canadian Family Physician, 53(10), 1704-1711.
 
Beyond Pesticides (n.d). What Is Integrated Pest Management (IPM)? Retrieved from https://www.beyondpesticides.org/ assets/media/documents/infoservices/pcos/What%20is%20IPM.pdf
 
Blair, A., Malker, H., Cantor, K. P., Burmeister, L., & Wiklund, K. (1985). Cancer among farmers: a review. Scandinavian Journal of Work, Environment and Health, 11(6), 397-407.
https://doi.org/10.5271/sjweh.2208
 
Boedeker, W., Watts, M., Clausing, P., & Marquez, E. (2020). The global distribution of acute unintentional pesticide poisoning: estimations based on a systematic review. BMC Public Health, 20, Article number 1875.
https://doi.org/10.1186/s12889-020-09939-0
 
Brown, T. P., Rumsby, P. C., Capleton, A. C., Rushton, L., & Levy, L. S. (2006). Pesticides and Parkinson's disease-is there a link? Environmental Health Perspectives, 114(2), 156-164.
https://doi.org/10.1289/ehp.8095
 
BYJU'S (2019). Pesticides. BYJU'S. Retrieved from https://byjus.com/chemistry/pesticides/.
 
Chen, Z., Wu, R., Wei, D., Wu, X., Ma, C., Shi, J., Geng, J., Zhao, M., Guo, Y., Xu, H., & Mao, Z. (2024). New findings on the risk of hypertension from organophosphorus exposure under different glycemic statuses: The key role of lipids? Science of The Total Environment, 930, 172711.
https://doi.org/10.1016/j.scitotenv.2024.172711
 
Chin-Chan, M., Navarro-Yepes, J., & Quintanilla-Vega, B. (2015). Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases. Frontiers in Cellular Neuroscience, 9, 124.
https://doi.org/10.3389/fncel.2015.00124
 
Cleveland Clinic (2024). Antifugals. Retrieved from https://my.clevelandclinic.org/health/drugs/21715-antifungals.
 
Cooper, J., & Dobson, H. (2007). The benefits of pesticides to mankind and the environment. Crop Protection, 26(9), 1337-1348.
https://doi.org/10.1016/j.cropro.2007.03.022
 
Coulibaly, T. P., Du, J., & Diakité, D. (2021). Sustainable agricultural practices adoption. Agriculture, 67(4), 166-176.
https://doi.org/10.2478/agri-2021-0015
 
Crop Life India (n.d.). Eight benefits of pesticides. Crop Life India. Retrieved from https://croplifeindia.org/2017/09/18/eight-benefits-of-pesticides/
 
Crop Life International (2014). Integrated Pest management. Retrieved from https://croplife.org/wp-content/uploads/2014/ 05/Integrated-pest-management.pdf.
 
Cupp, A. R., Smerud, J. R., Thomas, L. M., Waller, D. L., Smith, D. L., Erickson, R. A., & Gaikowski, M. P. (2020). Toxicity of carbon dioxide to freshwater fishes: implications for aquatic invasive species management. Environmental toxicology and chemistry, 39(11), 2247-2255.
https://doi.org/10.1002/etc.4855
 
Czajka, M., Matysiak-Kucharek, M., Jodłowska-Jędrych, B., Sawicki, K., Fal, B., Drop, B., Kruszewski, M., & Kapka-Skrzypczak, L. (2019). Organophosphorus pesticides can influence the development of obesity and type 2 diabetes with concomitant metabolic changes. Environmental Research, 178, 108685.
https://doi.org/10.1016/j.envres.2019.108685
 
Damalas, C. A. (2009). Understanding benefits and risks of pesticide use. Scientific Research and Essay, 4(10), 945-949.
 
Dhillon, A. S., Tarbutton, G. L., Levin, J. L., Plotkin, G. M., Lowry, L. K., Nalbone, J. T., & Shepherd, S. (2008). Pesticide/ environmental exposures and Parkinson's disease in East Texas. Journal of agromedicine, 13(1), 37-48.
https://doi.org/10.1080/10599240801986215
 
Diabetes and the Environment (n.d.). Pesticides. Retrieved from https://www.diabetesandenvironment.org/home/environmental-chemicals/pesticides.
 
Dick, F. D. (2006). Parkinson's disease and pesticide exposures. British Medical Bulletin, 79(1), 219-231.
https://doi.org/10.1093/bmb/ldl018
 
Earles, R., & Williams, P. (2005). Sustainable agriculture: An introduction. AATRA. Retrieved from https://s3.wp.wsu.edu/ uploads/sites/2079/2015/06/Sustainable-Agriculture-An-Intoduction-ATTRA.pdf.
 
Edwards, C. A. (1993). The impact of pesticides on the environment. In The pesticide question: Environment, economics, and ethics (pp. 13-46). Boston, MA: Springer US.
https://doi.org/10.1007/978-0-585-36973-0_2
 
Environmental Factor (2022). Pesticide exposure on Thai farms mapped by NIEHS-funded scientists. Retrieved from https://factor.niehs.nih.gov/2022/2/papers/pesticide-exposure.
 
European Food Safety Authority (EFSA), Adriaanse, P., Arce, A., Focks, A., Ingels, B., Jölli, D., ... & Auteri, D. (2023). Revised guidance on the risk assessment of plant protection products on bees (Apis mellifera, Bombus spp. and solitary bees). EFSA Journal, 21(5), e07989.
https://doi.org/10.2903/j.efsa.2023.7989
 
Fang, L., Liao, X., Jia, B., Shi, L., Kang, L., Zhou, L., & Kong, W. (2020). Recent progress in immunosensors for pesticides. Biosensors and Bioelectronics, 164, 112255.
https://doi.org/10.1016/j.bios.2020.112255
 
Fenik, J., Tankiewicz, M., & Biziuk, M. (2011). Properties and determination of pesticides in fruits and vegetables. TrAC Trends in Analytical Chemistry, 30(6), 814-826.
https://doi.org/10.1016/j.trac.2011.02.008
 
Fernández-Quiroz, D., Tohidi, M. M., Paymard, B., & Lucero-Acuña, A. (2023). Immobilization of essential oils in biopolymeric matrices: recent approaches for controlled delivery systems. Studies in Natural Products Chemistry, 78, 365-401.
https://doi.org/10.1016/B978-0-323-91253-2.00005-4
 
Food and Agricultural Organisation of the United Nations (2023). World food and agriculture - Statistical yearbook. Retrieved from http://www.fao.org/documents/card/en/c/cc8166en
 
Fourdinier, G. (2017). The origins of pesticides. Agricool. Retrieved from https://medium.com/welcome-to-agricool/the-origins-of-pesticides-209c503a86dc.
 
Garrigou, A., Laurent, C., Berthet, A., Colosio, C., Jas, N., Daubas-Letourneux, V., Jackson Filho, J. M., Jouzel, J. N., Samuel, O., Baldi, I., & Judon, N. (2020). Critical review of the role of PPE in the prevention of risks related to agricultural pesticide use. Safety science, 123, 104527.
https://doi.org/10.1016/j.ssci.2019.104527
 
Got Pests (2022). Is it a Pest? Retrieved from https://www.maine. gov/dacf/php/gotpests/whatisapest/index.shtml.
 
Gupta, R. C., & Crissman, J. W. (2013). Chapter 42 - Agricultural Chemicals: Safety assessment including currency and emergency issues in toxicological pathology. In Haschek and Rousseaux's Handbook of Toxicologic Pathology (Third Edition) (Volume II, pp. 1349-1372). Science Direct. Retrieved from https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/algaecide.
https://doi.org/10.1016/B978-0-12-415759-0.00042-X
 
Hancock, D. B., Martin, E. R., Mayhew, G. M., Stajich, J. M., Jewett, R., Stacy, M. A., Scott, B.L., Vance, J. M., & Scott, W. K. (2008). Pesticide exposure and risk of Parkinson's disease: a family-based case-control study. BMC neurology, 8, Article number 6.
https://doi.org/10.1186/1471-2377-8-6
 
Hatcher, J. M., Pennell, K. D., & Miller, G. W. (2008). Parkinson's disease and pesticides: A toxicological perspective. Trends in Pharmacological Sciences, 29(6), 322-329.
https://doi.org/10.1016/j.tips.2008.03.007
 
Heck, J. (2022). These pesticides may increase cancer risk in children. University of California. Retrieved from https://www.universityofcalifornia.edu/news/these-pesticides-may-increase-cancer-risk-children
 
Hobbs, P. R., Sayre, K., & Gupta, R. (2008). The role of conservation agriculture in sustainable agriculture. Philosophical Transactions of the Royal Society B: Biological Sciences, 363(1491), 543-555.
https://doi.org/10.1098/rstb.2007.2169
 
Horn, R., Holthusen, D., Dörner, J., Mordhorst, A., & Fleige, H. (2019). Scale-dependent soil strengthening processes-What do we need to know and where to head for a sustainable environment? Soil and Tillage Research, 195, 104388.
https://doi.org/10.1016/j.still.2019.104388
 
Inobeme, A., Mathew, J. T., Okonkwo, S., Ajai, A. I., Jacob, J. O., & Olori, E. (2023) Pesticides residue in food distribution route of exposure and toxicity: In review. MOJ Food Processing and Technology, 8(3), 121-124.
https://doi.org/10.15406/mojfpt.2020.08.00251
 
Jenkins, J. L., & Rodgers, G. B. (2020). Combining measures of risk exposure with injury incidence estimates to estimate nursery product injury rates. Journal of safety research, 72, 41-46.
https://doi.org/10.1016/j.jsr.2019.12.006
 
Jia, C., Qiu, G., Wang, H., Zhang, S., An, J., Cheng, X., Li, P., Li, W., Zhang, X., Yang, H., & He, M. (2023). Lipid metabolic links between serum pyrethroid levels and the risk of incident type 2 diabetes: A mediation study in the prospective design. Journal of Hazardous Materials, 459, 132082.
https://doi.org/10.1016/j.jhazmat.2023.132082
 
Jia, C., Zhang, S., Cheng, X., An, J., Zhang, X., Li, P., Li, W., Wang, X., Yuan, Y., Zheng, H., & He, M. (2022). Association between serum pyrethroid insecticide levels and incident type 2 diabetes risk: a nested case-control study in Dongfeng-Tongji cohort. European Journal of Epidemiology, 37(9), 959-970.
https://doi.org/10.1007/s10654-022-00906-0
 
Kampouraki, M., Mavridou, K., Bakola, M., Kitsou, K. S., & Karanasios, D. (2023). Can sulfonylureas for agricultural use cause diabetes? A report of three cases. Cureus, 15(3), e35938.
https://doi.org/10.7759/cureus.35938
 
Kaur, N., Starling, A. P., Calafat, A. M., Sjodin, A., Clouet-Foraison, N., Dolan, L. M., Imperatore, G., Jensen, E. T., Lawrence, J. M., Ospina, M., & Jaacks, L. M. (2020). Longitudinal association of biomarkers of pesticide exposure with cardiovascular disease risk factors in youth with diabetes. Environmental Research, 181, 108916.
https://doi.org/10.1016/j.envres.2019.108916
 
Khalil, Y., Ashworth, M. B., Han, H., Qin, Y., Rocha, R. L., Pritchard, B., Cameron, D., & Beckie, H. J. (2021). Identification of the first glyphosate‐resistant capeweed (Arctotheca calendula) population. Pest Management Science, 77(5), 2568-2575.
https://doi.org/10.1002/ps.6295
 
Landis, S. H., Murray, T., Bolden, S., & Wingo, P. A. (1998). Cancer statistics, 1998. CA: A Cancer Journal for Clinicians, 48(1), 6-29.
https://doi.org/10.3322/canjclin.48.1.6
 
Lari, S., Yamagani, P., Pandiyan, A., Vanka, J., Naidu, M., Senthil Kumar, B., Jee, B., & Jonnalagadda, P. R. (2023). The impact of the use of personal-protective-equipment on the minimization of effects of exposure to pesticides among farm-workers in India. Frontiers in Public Health, 11, 1075448.
https://doi.org/10.3389/fpubh.2023.1075448
 
Lengai, G. M., & Muthomi, J. W. (2018). Biopesticides and their role in sustainable agricultural production. Journal of Biosciences and Medicines, 6(6), 7-41.
https://doi.org/10.4236/jbm.2018.66002
 
Lynge, E., Anttila, A, Hemminki, K. (1997). Organic solvents and cancer. Cancer Causes Control, 8(3), 406-19
https://doi.org/10.1023/A:1018461406120
 
Mahmood, I., Imadi, S. R., Shazadi, K., Gul, A., & Hakeem, K. R. (2016). Effects of pesticides on environment. Plant, soil and microbes: volume 1: implications in crop science (pp. 253-269). Springer International Publishing
https://doi.org/10.1007/978-3-319-27455-3_13
 
McBurney, J. W. (2017). 8 pesticides and neurodegenerative disorders. In: Integrative Environmental Medicine (pp. 175-196). Oxford Academic Retrieved from https://academic.oup. com/book/24751/chapter/188264425.
https://doi.org/10.1093/med/9780190490911.003.0008
 
McEachran, A. D., Blackwell, B. R., Hanson, J. D., Wooten, K. J., Mayer, G. D., Cox, S. B., & Smith, P. N. (2015). Antibiotics, bacteria, and antibiotic resistance genes: aerial transport from cattle feed yards via particulate matter. Environmental Health Perspectives, 123(4), 337-343.
https://doi.org/10.1289/ehp.1408555
 
Mishra, P. K., Kumar, A., Kumar, P., Aman A. A., & Bajpeyi, M. M. (2023). Modern aspects of entomology. Integrated Publications. Retrieved from https://www.integratedpublications.in/books/1684585451-modern-aspects-of-entomology.
https://doi.org/10.22271/int.book.261
 
Mostafalou, S., & Abdollahi, M. (2013). Pesticides and human chronic diseases: Evidences, mechanisms, and perspectives. Toxicology and Applied Pharmacology, 268(2), 157-177.
https://doi.org/10.1016/j.taap.2013.01.025
 
Mostafalou, S., & Abdollahi, M. (2013). Pesticides and human chronic diseases: evidences, mechanisms, and perspectives. Toxicology and applied pharmacology, 268(2), 157-177.
https://doi.org/10.1016/j.taap.2013.01.025
 
Moura, D. D., Borges, V., Ferraz, H. B., Schuh, A. F., de Mello Rieder, C. R., Mata, I. F., Brito, M. M. C. M., Tumas, V., & Santos-Lobato, B. L. (2023). History of high household pesticide use and Parkinson's disease in Brazil. Parkinsonism & Related Disorders, 113, 105493.
https://doi.org/10.1016/j.parkreldis.2023.105493
 
Naksata, M., Watcharapasorn, A., Hongsibsong, S., & Sapbamrer, R. (2020). Development of personal protective clothing for reducing exposure to insecticides in pesticide applicators. International journal of environmental research and public health, 17(9), 3303.
https://doi.org/10.3390/ijerph17093303
 
Nalage, D., Sontakke, T., Kale, R., Patil, K., & Dange, V. (eds.) (2023); Integrated pest management. Gaurang Publishing Globalize Private Limited, Mumbai. Pp. 1-89.
 
National Institute of Environmental Health Sciences (2023). Pesticides. Retrieved from https://www.niehs.nih.gov/health/ topics/agents/pesticides.
 
National Library of Medicine (1993). Pesticides in the diets of infants and children. Retrieved from https://www.ncbi.nlm.nih. gov/books/NBK236265/.
 
National Pesticides Information Center (2023). Types of pesticides. Retrieved from http://npic.orst.edu/ingred/ ptype/index.html.
 
O'Donnel, P. (2024). Neurodegeneration Disorder. UTSouthern Medical Center. Retrieved from https://utswmed.org/ conditions-treatments/neurodegenerative-disorders/
 
Oluwole, O., & Cheke, R. A. (2009). Health and environmental impacts of pesticide use practices: A case study of farmers in Ekiti State, Nigeria. International Journal of Agricultural Sustainability, 7(3), 153-163.
https://doi.org/10.3763/ijas.2009.0431
 
Owens, K., Feldman, J., & Kepner, J. (2010). Wide range of diseases linked to pesticides. Pesticides and You, 30(2), 13-21.
 
Pedroso, T. M. A., Benvindo-Souza, M., de Araújo Nascimento, F., Woch, J., Dos Reis, F. G., & de Melo e Silva, D. (2022). Cancer and occupational exposure to pesticides: a bibliometric study of the past 10 years. Environmental Science and Pollution Research, 29(12), 17464-75.
https://doi.org/10.1007/s11356-021-17031-2
 
Pest Action and Agroecology Network (n.d.). Pesticides and cancer. Retrieved from https://www.panna.org/resources/ pesticides-and-cancer/#:~:text=When%20either%20parent% 20is%20exposed,higher%20rates%20of%20a%20cancer.
 
Pesticide Action Network UK (2017). Impacts of pesticides on the environment. Retrieved from https://www.pan-uk.org/our-environment/.
 
Pesticides Facts (n.d.). Importance and benefits of pesticides. Pesticides Facts. Retrieved from https://pesticidefacts.org/topics/necessity-of-pesticides/
 
Pimentel, D., Acquay, H., Biltonen, M., Rice, P., Silva, M., Nelson, J., Lipner, V., Giordano, S., Horowitz, A., & D'amore, M. (1992). Environmental and economic costs of pesticide use. BioScience, 42(10), 750-760.
https://doi.org/10.2307/1311994
 
Pinkert, S., & Zeuss, D. (2018). Thermal biology: melanin-based energy harvesting across the tree of life. Current Biology, 28(16), R887-R889.
https://doi.org/10.1016/j.cub.2018.07.026
 
Rajak, P., Roy, S., Ganguly, A., Mandi, M., Dutta, A., Das, K., Nanda, S., Ghanty, S., & Biswas, G. (2023). Agricultural pesticides-friends or foes to biosphere? Journal of Hazardous Materials Advances, 10, 100264.
https://doi.org/10.1016/j.hazadv.2023.100264
 
Rattanawitoon, T., Siriwong, W., Shendell, D., Fiedler, N., & Robson, M. G. (2023). An Evaluation of a Pesticide Training Program to Reduce Pesticide Exposure and Enhance Safety among Female Farmworkers in Nan, Thailand. International Journal of Environmental Research and Public Health, 20(17), 6635.
https://doi.org/10.3390/ijerph20176635
 
Rodríguez-Gómez, I., Santalla, A., Diez-Bermejo, J., Munguía-Izquierdo, D., Alegre, L. M., Nogales-Gadea, G., Arenas, J., Martín, M.A., Lucia, A., & Ara, I. (2020). Sex differences and the influence of an active lifestyle on adiposity in patients with McArdle disease. International Journal of Environmental Research and Public Health, 17(12), 4334.
https://doi.org/10.3390/ijerph17124334
 
Rugbjerg, K., Harris, M. A., Shen, H., Marion, S. A., Tsui, J. K., & Teschke, K. (2011). Pesticide exposure and risk of Parkinson's disease-a population-based case-control study evaluating the potential for recall bias. Scandinavian Journal of Work, Environment & Health, 37(5), 427-436.
https://doi.org/10.5271/sjweh.3142
 
Saldana, T. M., Basso, O., Hoppin, J. A., Baird, D. D., Knott, C., Blair, A., Alavanja, M. C., & Sandler, D. P. (2007). Pesticide exposure and self-reported gestational diabetes mellitus in the Agricultural Health Study. Diabetes care, 30(3), 529-534.
https://doi.org/10.2337/dc06-1832
 
Schwingl, P. J., Lunn, R. M., & Mehta, S. S. (2021). A tiered approach to prioritizing registered pesticides for potential cancer hazard evaluations: implications for decision making. Environmental Health, 20, Article number 13.
https://doi.org/10.1186/s12940-021-00696-0
 
Science (2013). Infographic: pesticide planet. Science, 341(6147), 730-731. Retrieved from https://doi.org/10.1126/science.341.6147.730.
https://doi.org/10.1126/science.341.6147.730
 
Shapiro, G. D., Dodds, L., Arbuckle, T. E., Ashley-Martin, J., Ettinger, A. S., Fisher, M., Taback, S., Bouchard, M. F., Monnier, P., Dallaire, R., & Fraser, W. (2016). Exposure to organophosphorus and organochlorine pesticides, perfluoroalkyl substances, and polychlorinated biphenyls in pregnancy and the association with impaired glucose tolerance and gestational diabetes mellitus: The MIREC Study. Environmental Research, 147, 71-81.
https://doi.org/10.1016/j.envres.2016.01.040
 
Simões-Wüst, A. P., Moltó-Puigmartí, C., Jansen, E. H., van Dongen, M. C., Dagnelie, P. C., & Thijs, C. (2017). Organic food consumption during pregnancy and its association with health-related characteristics: the KOALA Birth Cohort Study. Public Health Nutrition, 20(12), 2145-2156.
https://doi.org/10.1017/S1368980017001215
 
Singh, R., Kumar, N., Mehra, R., Kumar, H., & Singh, V. P. (2020). Progress and challenges in the detection of residual pesticides using nanotechnology based colorimetric techniques. Trends in Environmental Analytical Chemistry, 26, e00086.
https://doi.org/10.1016/j.teac.2020.e00086
 
Sparks, T. C., & Bryant, R. J. (2021). Crop protection compounds-trends and perspective. Pest Management Science, 77(8), 3608-3616.
https://doi.org/10.1002/ps.6293
 
Sparks, T. C., & Lorsbach, B. A. (2023). Insecticide discovery-"Chance favors the prepared mind". Pesticide Biochemistry and Physiology, 192, 105412.
https://doi.org/10.1016/j.pestbp.2023.105412
 
Stoytcheva, M. (2011). Pesticides in the modern world. IntechOpen. Retrieved from https://www.intechopen.com/ books/432.
https://doi.org/10.5772/950
 
Sugimura, T., Inoue, R., Ohgaki, H., Ushijima, T., Canzian, F., & Nagao, M. (1995). Genetic polymorphisms and susceptibility to cancer development. Pharmacogenetics and Genomics, 5, S161-S165.
https://doi.org/10.1097/00008571-199512001-00020
 
Sustainable Agriculture Research & Education Program (SAREP) (n.d). What is sustainable agriculture? Retrieved from https://agritech.tnau.ac.in/pdf/sustainableagriculture.pdf.
 
Tudi, M., Daniel Ruan, H., Wang, L., Lyu, J., Sadler, R., Connell, D., Chu, C., & Phung, D. T. (2021). Agriculture development, pesticide application and its impact on the environment. International journal of environmental research and public health, 18(3), 1112.
https://doi.org/10.3390/ijerph18031112
 
Umetsu, N., & Shirai, Y. (2020). Development of novel pesticides in the 21st century. Journal of Pesticide Science, 45(2), 54-74.
https://doi.org/10.1584/jpestics.D20-201
 
United Nations (2021). Environmental and health impacts of pesticides and fertilizers and ways of minimizing them. United Nations Environment Programme. Retrieved from https://www.fao.org/fileadmin/user_upload/soils/publications/pesticides.pdf
 
Walsh, L., Hill, C., & Ross, R. P. (2023). Impact of glyphosate (Roundup TM) on the composition and functionality of the gut microbiome. Gut Microbes, 15(2), 2263935.
https://doi.org/10.1080/19490976.2023.2263935
 
Wei, Y., Wang, L., & Liu, J. (2023). The diabetogenic effects of pesticides: Evidence based on epidemiological and toxicological studies. Environmental Pollution, 331, 121927.
https://doi.org/10.1016/j.envpol.2023.121927
 
Wigenstam, E., Forsberg, E., Bucht, A., & Thors, L. (2021). Efficacy of atropine and scopolamine on airway contractions following exposure to the nerve agent VX. Toxicology and Applied Pharmacology, 419, 115512.
https://doi.org/10.1016/j.taap.2021.115512
 
Xiao, X., Clark, J. M., & Park, Y. (2017). Potential contribution of insecticide exposure and development of obesity and type 2 diabetes. Food and Chemical Toxicology, 105, 456-474.
https://doi.org/10.1016/j.fct.2017.05.003
 
Yarpuz-Bozdogan, N. (2018). The importance of personal protective equipment in pesticide applications in agriculture. Current Opinion in Environmental Science & Health, 4, 1-4.
https://doi.org/10.1016/j.coesh.2018.02.001
 
Yu, G., Su, Q., Chen, Y., Wu, L., Wu, S., & Li, H. (2021). Epigenetics in neurodegenerative disorders induced by pesticides. Genes and Environment, 43, Article number 55.
https://doi.org/10.1186/s41021-021-00224-z
 
Zahm, S. H., Ward, M. H., & Blair, A. (1997). Pesticides and cancer. Occupational Medicine-State of the Art Reviews, 12(2), 269-290.
 
Zhao, L., Liu, Q., Jia, Y., Lin, H., Yu, Y., Chen, X., Liu, Z., Li, W., Fang, T., Jiang, W., & Guo, L. (2023). The Associations between Organophosphate Pesticides (OPs) and Respiratory Disease, Diabetes Mellitus, and Cardiovascular Disease: A Review and Meta-Analysis of Observational Studies. Toxics, 11(9), 741.
https://doi.org/10.3390/toxics11090741