Integrity Research Journals

ISSN: 2705-2222
Model: Open Access/Peer Reviewed
DOI: 10.31248/JDPS
Start Year: 2016
Email: jdps@integrityresjournals.org

JDPS Articles

Bryophyllum Pinnatum: A Mini Review On Ethnobotany And Phytochemistry
Bryophyllum pinnatum is from the family crassuliaceae. It is used in folk medicine to treat ailments such as dysentery, hypertersion, boil and so on. It contains a wide range of active phytochemical compounds including alkaloids, terpenes, glycosides and flavonoids. It has been known to process some biological activities This review focus on its biological... Continue here

Anti-inflammatory And Anti-nociceptive Potentials Of Salacia Lehmbachii Leaves
For decades, the leaves of Salacia lehmbachii Loes (SL), which belong to the family of Celastraceae are acceptably used in south-eastern parts of Nigeria in traditional medicine for the treatment of fever and painful conditions. This study assessed the anti-inflammatory and anti-nociceptive effects of its water extracts on inflammation and nociception in rats.... Continue here

Probing The Binding Sites, Global Energy And Molecular Interactions Between Ponatinib, Cabozantinib And Sunitinib Anticancer Drugs With Vascular Endothelial Growth Factor
Global Energy, binding sites and molecular interactions between ponatinib, cabozantinib and sunitinib anticancer drugs with vascular endothelial growth factor was probed to find the best binding energy at the active site. The structures of ponatinib, cabozantinib and sunitinib were drawn and constructed using window based program of ArgusLab and ACDlab ChemSketch... Continue here

Determination Of Antibacterial Activity Of Essential Oils From Mint (mentha Spicata) Leaves On Selected Pathogenic Bacteria
Drug resistant pathogenic microorganisms account for the highest proportion of death today. This study was aimed at extracting essential oils (EOS) from mint. Sensitivity tests of selected pathogenic microorganism were also carried out. EOS were extracted using distillation method. Phytochemical screening of the essential oils for the presence of tannins,... Continue here

Antidepressant Effects Of The Hydro-alcoholic Extract And Fractions Of Anchomanes Difformis (blume) Engler Rhizome (family Araceae) In Mice
In ethno-medicinal practice in the South-western part of Nigeria, the rhizome of Anchomanes difformis is claimed to be effective in the management of mental illness. This study determined the antidepressant effects of hydro-alcoholic extract and fractions of Anchomanes difformis rhizome and the likely mechanisms of action of the extract and the most active... Continue here

The Perception Of Healthcare Providers On The Quality Of Locally Made Drugs And Imported Drugs
Locally made drugs are an important policy way of reducing out-of-pocket expenditure on medicines. Therefore, negative perceptions of their quality affect utilization and raise issues of confidence and trust in medicines and health services. This study examines the perception of healthcare professionals to locally made drugs in relation to their understanding and... Continue here

An Overview Of The Therapeutic Functions Of Ginger
Ginger (Zinger officinale Roscoe, Zingiberaceae) is mainly consumed as food condiments globally. It is one of the most widely used natural products. Ginger has long been used as an important ingredient in cooking and traditional herbal Medicine. It contains many bioactive constituents, which have notable pharmacological and physiological properties. Ginger is... Continue here

Affordability Issues Of Biotech Drugs In Low- And Middle-income Countries
Pharmaceutical companies invest in the development and testing of their drugs including funding clinical trials. Furthermore, pharmaceutical companies also spend a large amount of money on advertising. For instance, in 2016 US$6.7 billion was spent on direct-to-consumer pharmaceutical advertising alone in the USA. Worldwide spending on medicines reached $1.2... Continue here

Intermittent Fasting And Adding More Days To Life
With over 50% of the adult population in the UK currently classified as overweight or obese, accompanied by an increased risk of type 2 diabetes and cardiovascular disease, finding more effective strategies to manage these conditions remains imperative. In 2016, World Health Organization (WHO) reported that more than 1.9 billion people in the world were overweight... Continue here

Neurobehavioural Effects Of Vigna Unguiculata Spp Dekindtiana (l.) Walp In Mice
The study investigated the pharmacological effects of the extract and fractions of Vigna unguiculata spp dekindtiana. The neurobehavioural parameters investigated in this study include: rearing, grooming and locomotion as well as pentobarbital-induced sleeping time model as a measure of the sedative effect of the plant. The neuropharmacological profile of the... Continue here

Gas Chromatography Mass Spectrometry And Fourier Transform Infrared Spectroscopy Analysis Of Methanolic Extract Of Mimosa Pudica L. Leaves
The present study investigates the chemical constituents of a traditionally used ethno-medicinal plant Mimosa pudica Linn using Gas Chromatography Mass Spectrometry (GC/MS) and Fourier Transform Infrared Spectroscopy (FTIR). The identification of phytochemical compounds was based on the peak area, retention time, molecular weight, molecular formula, MS fragment... Continue here

Phytochemicals, Acute Toxicity And In-vitro Antioxidant Activity Of Ethanol Extract Of Sphenocentrum Jollyanum Leaves
Medicinal plants possess strong antioxidants that help to scavenge and protect the human health against several diseases caused by free radicals. This study was carried out to evaluate the phytochemical constituents, acute toxicity and antioxidant activity of the ethanol extract of Sphenocentrum jollyanum leaves in order to validate the medicinal potential of this... Continue here

A Comparative Qsar Analysis, 3d-qsar, Molecular Docking And Molecular Design Of Iminoguanidine-based Inhibitors Of Hemo: A Rational Approach To Antibacterial Drug Design
QSAR models of 25 iminoguanidine derivatives with inhibitory HemO were developed. The QSAR model was built by using DFT-MLR and the best QSAR model has R2, Q2 values of 0.6569 and 0.5493 for cross-validated and non-cross-validated. The predictive ability of QSAR model was further validated by a test set of 7 compounds, giving R2pred value of 0.7123. 3D-QSAR and... Continue here

Quality Assessment Of Five Pharmaceutical Products Of Different Brands Marketed In Nigeria
Many pharmaceutical products have been reported to be substandard and counterfeit. About 15% of all drugs circulating in some parts of Africa and Asia are believed to be counterfeit, with figures rising to as high as 50%. This study was therefore carried out to assess the quality of five groups of drugs of different brands manufactured by pharmaceutical companies... Continue here

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