JOURNAL OF DRUGS AND PHARMACEUTICAL SCIENCE
Integrity Research Journals
ISSN: 2705-2222
Model: Open Access/Peer Reviewed
DOI: 10.31248/JDPS
Start Year: 2016
Email: jdps@integrityresjournals.org
An overview of the therapeutic functions of ginger
https://doi.org/10.31248/JDPS2019.020 | Article Number: BB4FE06B1 | Vol.3 (2) - June 2019
Received Date: 03 April 2019 | Accepted Date: 28 June 2019 | Published Date: 30 June 2019
Authors: Kayode Azeez Abideen Abolanle* and Kayode Omowumi Titilola
Keywords: therapeutic., Ginger, pharmacological, physiological, rhizome, Zinger officinale.
Ginger (Zinger officinale Roscoe, Zingiberaceae) is mainly consumed as food condiments globally. It is one of the most widely used natural products. Ginger has long been used as an important ingredient in cooking and traditional herbal Medicine. It contains many bioactive constituents, which have notable pharmacological and physiological properties. Ginger is employed in the treatment of several diseases. This review gives an overview of the chemical composition of ginger and its many dietary and therapeutic uses.
| Aggarwal, B. B., Kunnumakkara, A. B., Harikumar, K. B., Tharakan, S. T., Sung, B., & Anand, P. (2008). Potential of spice-derived phytochemicals for cancer prevention. Planta Medica, 74(13), 1560-1569. Crossref |
||||
| Ahmed, R. S., Suke, S. G., Seth, V., Chakraborti, A., Tripathi, A. K., & Banerjee, B. D. (2008). Protective effects of dietary ginger (Zingiber officinales Rosc.) on lindane‐induced oxidative stress in rats. Phytotherapy Research, 22(7), 902-906. Crossref |
||||
| Beg, T., Siddique, Y. H., Ara, G., Gupta, J., & Afzal, M. (2008). Antigenotoxic effect of genistein and gingerol on genotoxicity induced by norethandrolone and oxandrolone in cultured human lymphocytes. International Journal of Pharmacology, 4(3), 177-183. Crossref |
||||
| Bhatt, N., Waly, M. I., Essa, M. M., & Ali, A. (2013). Ginger: A functional herb. In Food as Medicine. (pp. 51-72). Nova Science Publishers, Inc. | ||||
| Black, C. D., & O'Connor, P. J. (2008). Acute effects of dietary ginger on quadriceps muscle pain during moderate-intensity cycling exercise. International Journal of Sport Nutrition and Exercise Metabolism, 18(6), 653-664. Crossref |
||||
| Bode, A. M., & Dong, Z. (2011). The amazing and mighty ginger. In: Herbal medicine: Biomolecular and clinical aspects. 2nd edition. Benzie, I. F. F., Wachtel-Galor, S. (eds.). Boca Raton (FL): CRC Press/Taylor & Francis. | ||||
| Borrelli, F., Capasso, R., Aviello, G., Pittler, M. H., & Izzo, A. A. (2005). Effectiveness and safety of ginger in the treatment of pregnancy-induced nausea and vomiting. Obstetrics and Gynecology, 105(4), 849-856. Crossref |
||||
| Bruneton, Jean. (1995). Ginger: Pharmacognosy, Phytochemistry, Medicinal plants. Lavoisier publishing Co. Inc. Pp. 258-261. | ||||
| Castleman M. (2001). The new healing herbs. 2nd edition. Emmaus, Pennsylvania: Rodale Press. Pp. 301-308. | ||||
| Chen, C. Y, Li, Y. W, & Kuo, S. Y. (2009). Effect of [10]-gingerol on [Ca2+]i and cell death in human colorectal cancer cells. Molecules, 14(3), 959-69. Crossref |
||||
| Choi, J. G., Kimb, S. Y., Jeong, M., & Oh, M. S. (2018). Pharmacotherapeutic potential of ginger and its compounds in age-related neurological disorders. Pharmacology and Therapeutics 182, 56-69. Crossref |
||||
| Der Marderosian, A., & Beutler, J. A. (2006). The review of natural products. St. Louis, MO: Wolters Kluwer. | ||||
| El-Sharaky, A. S., Newairy, A. A., Kamel, M. A., & Eweda, S. M. (2009). Protective effect of ginger extract against bromobenzene-induced hepatotoxicity in male rats. Food and Chemical Toxicology, 47(7), 1584-1590. Crossref |
||||
| Ernst, E., & Pittler, M. H., (2000). Efficacy of ginger for nausea and vomiting: A systematic review of randomized clinical trials. British Journal of Anaesthesia, 84, 367-371. Crossref |
||||
| Gugnani, H. C., & Ezenwanze, E. C. (1985). Antibacterial activity of extracts of ginger and African oil bean seed. The Journal of Communicable Diseases, 17(3), 233. | ||||
| Jolad, S. D., Lantz, R. C., Chen, G. J., Bates, R. B., & Timmermann, B. N. (2005). Commercially processed dry ginger (Zingiber officinale): Composition and effects on LPS-stimulated PGE2 production. Phytochemistry, 66(13), 1614-35. Crossref |
||||
| Kim, J. K., Kim, Y., Na, K. M., Surh, Y. J., & Kim, T. Y. (2007). [6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo. Free Radical Research, 41(5), 603-614. Crossref |
||||
| Koh, E. M., Kim, H. J., Kim, S., Choi, W. H., Choi, Y. H., Ryu, S. Y., Kim, Y. S., Koh, W. S., & Park, S. Y. (2009). Modulation of macrophage functions by compounds isolated from Zingiber officinale. Planta Medica, 75(02), 148-151. Crossref |
||||
| Minghetti, P., Sosa, S., Cilurzo, F., Casiraghi, A., Alberti, E., Tubaro, A., Della Loggia, R., & Montanari, L. (2007). Evaluation of the topical anti-inflammatory activity of ginger dry extracts from solutions and plasters. Planta Medica, 73(15), 1525-1530. Crossref |
||||
| Moon, M., Kim, H. G., Choi, J. G., Oh, H., Lee, P. K., Ha, S. K., Kim, S. Y., Park, Y., Huh, Y., Oh, S. M. (2014). 6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia. Biochemical and Biophysical Research Communications, 449, 8-13. Crossref |
||||
| Nicoll, R., & Henein, M. Y. (2009). Ginger (Zingiber officinale Roscoe): a hot remedy for cardiovascular disease? International Journal of Cardiology, 131(3), 408-409. Crossref |
||||
| Ody, P. (2000). Complete guide to medicinal herbs. 2nd Edition. London. Dorling-kinderesly. | ||||
| Qian, Q. H., Yue, W., Wang, Y. X., Yang, Z. H., Liu, Z. T., & Chen, W. H. (2009). Gingerol inhibits cisplatin-induced vomiting by down regulating 5-hydroxytryptamine, dopamine and substance P expression in minks. Archives of Pharmacal Research, 32(4), 565-573. Crossref |
||||
| Rahmani, A. H., Al shabrmi, F. M., & Aly, S. M. (2014). Active ingredients of ginger as potential candidates in the prevention and treatment of diseases via modulation of biological activities. International Journal of Physiology, Pathophysiology and Pharmacology, 6(2), 125. | ||||
| Schwertner, H. A., Rios, D. C., & Pascoe, J. E. (2006). Variation in concentration and labeling of ginger root dietary supplements. Obstetrics and Gynecology, 107(6), 1337-1343. Crossref |
||||
| Semwal, R. B., Semwal, D. K., Combrinck, S., Viljoen, A. M. (2015). Gingerols and shogaols: important nutraceutical principles from ginger. Phytochemistry, 117, 554-568. Crossref |
||||
| Srivastava, K. C., & Mustafa, T. (1992). Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders. Medical Hypotheses, 39(4), 342-348. Crossref |
||||
| Sukumaran, V., Park, S. C., & Giri, S. S. (2016). Role of dietary ginger Zingiber officinale in improving growth performances and immune functions of Labeo rohita fingerlings. Fish & Shellfish Immunology 57, 362-370. Crossref |
||||
| Talpur, A. D., Ikhwanuddin, M., & Bolong, A. M. A. (2013). Nutritional effects of ginger (Zingiber officinale Roscoe) on immune response of Asian sea bass, Lates calcarifer (Bloch) and disease resistance against Vibrio harveyi. Aquaculture, 400, 46-52. Crossref |
||||
| Ueki, S., Miyoshi, M., Shido, O., Hasegawa, J., & Watanabe, T. (2008). Systemic administration of [6]-gingerol, a pungent constituent of ginger, induces hypothermia in rats via an inhibitory effect on metabolic rate. European Journal of Pharmacology, 584(1), 87-92. Crossref |
||||
| White, B. (2007). Ginger: An overview. American Academy of Family Physicians, 75(11), 1689-1691. | ||||
| Yadav, S., Sharma, P. K., & Alam, M. A. (2016). Ginger Medicinal Uses and Benefits. European Journal of Pharmaceutical and Medical Research, 3(7), 127-135. | ||||
| Yamahara, J., Miki, K., Chisaka, T., Sawada, T., Fujimura, H., Tomimatsu, T., Nakano, K., Nohara, T. (1985). Cholagogic effect of ginger and its active constituents. Journal of Ethnopharmacology, 13(2), 217-225. Crossref |
||||
| Young, H. Y., Luo, Y. L., Cheng, H. Y., Hsieh, W. C., Liao, J. C., & Peng, W. H. (2005). Analgesic and anti-inflammatory activities of [6]-gingerol. Journal of Ethnopharmacology, 96(1-2), 207-210. Crossref |
||||
| Zadeh, J. B., & Kor, N. M. (2014). Physiological and pharmaceutical effects of Ginger (Zingiber officinale Roscoe) as a valuable medicinal plant. European Journal of Experimental Biology, 4(1), 87-90. | ||||
| Zhang, M., Viennois, E., Prasad, M., Zhang, Y., Wang, L., Zhang, Z., Han, M. K., Xiao, B., Xu, C., Srinivasan, S., Merlin, D. (2016). Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer. Biomaterials 101, 321-340. Crossref |
||||
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