JOURNAL OF BIOSCIENCE AND BIOTECHNOLOGY DISCOVERY
Integrity Research Journals

ISSN: 2536-7064
Model: Open Access/Peer Reviewed
DOI: 10.31248/JBBD
Start Year: 2016
Email: jbbd@integrityresjournals.org


Antibiotic susceptibility patterns of Uropathogenic Escherichia coli among patients with urinary tract infections in a tertiary care hospital in Maiduguri, North Eastern, Nigeria

https://doi.org/10.31248/JBBD2017.060   |   Article Number: 75E08EE63   |   Vol.3 (1) - February 2018

Received Date: 20 December 2017   |   Accepted Date: 22 January 2018  |   Published Date: 28 February 2018

Authors:  Mohammed Kachallah , Dalhatu Yusuf Bolus and Abdulrasheed Abdu

Keywords: Escherichia coli, uropathogenic, antimicrobial susceptibility, urinary tract infection, multi-drug resistance.

Escherichia coli (E. coli) has been identified as the most common uropathogenic bacterial pathogen with increasing resistance to antibiotics. Aetiology of urinary tract infections (UTI) and their antibiotic sensitivity patterns vary from time to time and across different areas. In Nigeria, studies on the prevalence and antimicrobial susceptibility patterns of clinical isolates from urinary tract infections are inadequate. Employing standardised microbiological methods, this study assessed the prevalence and antimicrobial susceptibility patterns of E. coli isolates from UTI in University of Maiduguri Teaching Hospital (a tertiary health care institution) in North Eastern, Nigeria. Uropathogenic E. coli (UPEC) accounted for 150 (62.50%) of 240 urine isolates. Lowest susceptibility was for Ampicillin 54 (36.0%), Ciprofloxacin 69 (46.0%) and Norfloxacin 72 (48.0%). More than 50% were susceptible to Levofloxacin and Streptomycin 71 (54.0%) each, Cefuroxime and Co-trimoxazole 78 (52.0%) each, while highest susceptibility was for Nitrofurantoin 117 (78.0%), Chloramphenicol 105 (70.0%) and Gentamicin 96 (64.0%). The isolates were commonly resistant to 9 (24.24%) of the ten (MARI of 0.9) classes of antimicrobial agents used in this study and all the isolates were multidrug-resistant.  There is a need for proper surveillance and development of hospital specific antibiograms to inform appropriate empiric therapy of urinary tract infections.

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