Integrity Research Journals

ISSN: 2536-7099
Model: Open Access/Peer Reviewed
DOI: 10.31248/JASVM
Start Year: 2016

The comparative effect of aqueous extracts of Mucuna pruriens and Telfairia occidentialis leaf on liver enzymes and serum protein of albino rats   |   Article Number: 79124B324   |   Vol.8 (4) - August 2023

Received Date: 09 June 2023   |   Accepted Date: 20 July 2023  |   Published Date: 30 August 2023

Authors:  Ada A. Akwari* and Archibong Nsa Archibong

Keywords: Alanine amino transferase, alkaline phosphatase, aspartate aminotransferase, hematopoietic, hepatoprotective, hepatotoxic.

An experiment was conducted to determine the comparative effect of aqueous leaf extract of Mucuna prurines and Telfairia occidentalis on liver enzymes and serum protein in albino rats. Complete randomised design was used to assign twenty (20) Albino rats into four (4) groups of five rats per cage. Group 1 (control) received rat feed and water only, Group 2 received 25 mg/kgbw of M. pruriens, Group 3 received 25 mg/kgbw of T. occidentalis while group 4 received 50 mg/kgbw dose equipotent concentration of T. occidentalis and M. pruriens. After 21 days, liver enzyme and serum protein were estimated. The result showed a significant (p<0.05) decrease in aspartate aminotransferase (AST) of all the experimental animals across the groups especially T. occidentalis (44.20±3.47 µ/L) treated group when compared with control (88.80±3.87 µ/L). Also, alanine aminotransferase (ALT) of M. pruriens (36.20± 0.98* µ/L) treated group was significantly increase whereas T. occidentalis (16.86 ± 2.69* µ/L) treated group was significantly decreased. The elevated ALT in M. pruriens treated group showed extract may cause liver damage since elevated ALP is a more specific indicator of liver damage. Alkaline phosphatase (ALP) was significantly deceased in all experimental animals across the groups when compared with the control. Serum protein result showed significant decrease in albumin level of all the experimental groups, however, globulin level was slightly increased in all the experimental groups. There was no significant difference in total protein of all the experimental groups. In conclusion, extract of T. occidentalis showed high hepatoprotective effect while extract of M. pruriens was hepatotoxic. The two extracts were generally low in protein. It is recommended that leaf extracts should be used singly, combination therapy should be avoided to reduce hepatotoxic effect of M. pruriens. T. occidentalis is hepatoprotective and highly recommended for use in control of anaemia.

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