ADVANCED JOURNAL OF CHEMISTRY RESEARCH
Integrity Research Journals
Model: Open Access/Peer Reviewed
DOI: 10.31248/AJCR
Start Year: 2022
Email: ajcr@integrityresjournals.org
Acute toxicological effect of glyphosate-based herbicide (round up) with cadmium as a co-contaminant on African catfish (Clarias gariepinus)
https://doi.org/10.31248/JAJCR2023.004 | Article Number: DDDE7C6F1 | Vol.1 (2) - August 2023
Received Date: 27 April 2023 | Accepted Date: 09 June 2023 | Published Date: 30 August 2023
Authors: TA Iyanda* , AF Ayesanmi , IJ Kade , M Sunday and OO Ajayi
Keywords: catfish, Roundup, cadmium, TBARS, ð- ALA D, Na+/ K+ ATPase.
The possible toxicological effect of Round Up (RU) interacting with cadmium on juvenile African catfish was investigated. Juvenile catfish of mean weight 30 ± 0.3 g and mean standard length of 15±0.1 cm were exposed to constant sublethal concentration of 10 mg/L RU glyphosate herbicide and varying sublethal concentrations of cadmium (4.0 and 4.5 mg/L) for 96 hours with physicochemical parameters analyzed concurrently. Thereafter, biochemical parameters were assayed in the liver and kidney of exposed catfish using standard conventional methods. The physicochemical parameters analyzed on the artificial pond were within the standard acceptable range for the culture and survival of catfish. A significant increase in the level of thiobarbituric acid reactive substances (TBARS) was observed in catfish exposed to RU + Cd2+ as the concentration of cadmium increased when compared with RU alone and control. Also, there was a significant reduction in the level of inherent antioxidants possessed by the exposed catfish tissues which were determined via DPPH, FRAP and GSH estimation. The deleterious effect of RU with cadmium was accompanied by a marked decrease in the activities of Na+/K+-ATPase and ð- ALA-D and an increase in the activities of purinergic enzymes in a concentration-dependent manner when compared with RU alone and control in the tissues examined. Finally, the toxicity of RU with cadmium was established via the harmful effect exerted on the liver and kidney tissue of exposed catfish which was examined through the estimation of liver and kidney function indices. Hence, the present study suggests that RU and cadmium leaching together into an aquatic environment can be considered to have an additive deleterious effect and significantly perturbs the physiology and morphology of aquatic organisms especially the catfish when compared with exposure to individual glyphosate and cadmium.
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